ECE2014 Poster Presentations Obesity (53 abstracts)
Association analysis of the D2 dopamine receptor gene Taq IA polymorphisms in a cohort of Belarus morbidly obese children and adolescents.
Elena Aksyonova 1 , Ayjan Seyitnazarova 1 , Anzhalika Solntsava 2 , Olga Zagrebaeva 2 , Hanna Mikhno 2 & Alexandr Sukalo 2
1Institute of Genetics and Cytology, Minsk, Belarus; 2Belarusian State Medical University, Minsk, Belarus.
Background: The A1 allele of the DRD2/ANKK1 Taq1A polymorphism (rs1800497) is associated with reduced striatal D2 receptor binding (Thompson et al., 1997; Pohjalainen et al.,1998). Associations between Taq1A polymorphism DRD2/ANKK1 gene and reward sensitivity including compulsive overeating were reported (Propper et al., 2008; Davis et al., 2008). To study the association of DRD2/ANKK1 Taq1A polymorphism (rs1800497) with obesity we started genotyping of children and adolescents with morbid obesity (BMI >30 kg/m2) and normal weight control group children and adolescents. Here we report preliminary results of our investigation.
Population and methods: Seventy obese children and adolescent (4–17 years old) and 164 normal-weight children (4–17 years old) were genotyped using PCR-RFLP analysis of polymorphic alleles rs1800497.
Results: According our preliminary results we didn’t find any significant differences DRD2/ANKK1 Taq1A polymorphism (rs1800497) SNP allele and genotypes frequencies between morbidly obese and normal-weight children and adolescents. Please, see the table.
We will continue this investigation in enlarged patient’s cohort. The analysis of DRD2/ANKK1 Taq1A genotype of morbidly obese children and adolescents in association with dopamine level and analysis of eating behavior including compulsive overeating will be carried out.
This research was grunted by State Scientific and Technical Programme ‘Experts and rehabilitation technologies’ task N02.07.
| Genotype % | Allele % | |||||
| n | A1A1 | A1A2 | A2A2 | A1 | A2 | |
| Obese | 70 | 8.6 | 24.3 | 67.1 | 20.7 | 79.3 |
| Girls | 31 | 9.7 | 25.8 | 64.5 | 22.6 | 77.4 |
| Boys | 39 | 7.7 | 23.1 | 69.2 | 19.2 | 80.8 |
| Control | 164 | 7.3 | 27.4 | 65.2 | 21.0 | 79.0 |
| Girls | 104 | 8.7 | 26.0 | 65.4 | 21.6 | 78.4 |
| Boys | 60 | 5.0 | 30.0 | 65.0 | 20.0 | 80.0 |
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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