Endocrine Abstracts

Aim of the study: To examine offspring of patients with simple obesity. To ascertain, if there are some disturbances in the carbohydrate or lipid metabolism or unknown type 2 diabetes in these subjects.

Method and subjects: Examined were 132 families, 108 families with obesity, and 24 families without obesity, the control group. Fourteen additional were excluded because of ascertained at the time of examination unknown type 2 diabetes in the parents. In all of the offspring and their parents performed were: weight, height, BMI, WHR HDL, TGD, LDL, and glycaemia HbA1c, in the offspring additional HOMA. The control group included 30 healthy subjects with a negative anamnesis of obesity and/or diabetes in the family.

Results: Observed was overweight and obesity in a high percentage, increased BMI, WHR, significant differences in the level of HDL, TGD, LDL, and HOMA between the examined and control group Additional introduced was HHR< HWRWMI< HJMI< Zot Zot4, and ZL. In seven of the examined offspring ascertained was unknown type 2 diabetes, in 8 morning hyperglycaemia, in 5 glucose intolerance.

Conclusion: i) In offspring of obese parents observed are obesity and disturbances in the carbohydrate, lipid metabolism and unknown diabetes. ii) In offspring of obese patients very important and necessary are repeated prophylactic investigations. iii) Useful will be an education about the prevention of obesity and diabetes. For a better analysis of the obesity is in our opinion important the examination of HHR(height to hip ratio) and HWR(height to waist ratio).