ECE2014 Poster Presentations Male reproduction (25 abstracts)
An analysis of the possible relationship circulating concentrations of ghrelin, LH, FSH, testosterone and inhibin B at the time of puberty in normal healthy boys
A A Naseem 1 , S S R Rizvi 1, , Urooj Anwer 1 , Sana Mehmood 1 , Nadia Perveen 1 , Ghazala Shaheen 1 , Sadia Saqib 1 , Faheem Tahir 3 & Mazhar Qayyum 1
1Department of Zoology, PMAS Arid Agriculture University, Rawalpindi, Pakistan; 2Department of Reproductive Physiology, National Institute of Health, Islamabad, Pakistan; 3Pakistan Science Foundation, Islamabad, Pakistan.
Ghrelin receptor GHSR1α is expressed in hypothalamo–pituitary–gonadal tissues. Ghrelin reduces GnRH secretion in pre-pubertal period and concentrations of ghrelin are positively correlated with testosterone at adulthood. Nevertheless, the role of ghrelin in affecting pituitary and gonadal functions during normal pubertal development remains elusive. A possible correlation between ghrelin and LH, FSH, testosterone and inhibin B was examined in boys (n=557) between 10 and 20 years. Blood samples were collected and plasma concentrations of ghrelin, LH, FSH, testosterone and inhibib B were determined by ELISA. Data were analyzed using Student’s t-test, ANOVA and Pearson correlation. The concentrations of ghrelin significantly increased at 11th and 14th years, markedly decreased till 16th year, increased significantly at 17th year, suddenly declined to low concentrations at 18th year to be maintained at later years. The concentrations of LH increased to a small peak at 12th year, an intermediate peak at 15th year and a highest peak at 18th year and then declined at 19th year to be maintained at 20th year. The concentrations of testosterone increased progressively till 13th year, abruptly increased to several fold at 15th year, augmented increasingly to reach highest concentrations at 18th year. The concentrations of FSH increased abruptly at 11th year, progressively increased to peak at 15th year and attained 2nd peak at 18th year. The concentrations of inhibin B progressively increased reaching a peak at 14th years and thereafter progressively declined to low concentrations at 20th year. The concentrations of ghrelin, LH, testosterone, FSH and inhibin B increased significantly at mid puberty. The concentrations of ghrelin were maintained, the levels of LH, testosterone and FSH continued to rise and the concentrations of inhibin B declined at late puberty/adolescence. In conclusion, the concentrations of ghrelin, LH, FSH, testosterone and inhibin B were positively correlated at early and mid puberty.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more