ECE2014 Poster Presentations Female reproduction (54 abstracts)
Serum leptin concentration in gestational diabetes
Oksana Kononova 1 , Vladimir Kalachev 3 , Valentina Sorogovec 2 , Elena Naumenko 2 , Volha Vasilkova 1, & Andrei Pristrom 4
1Gomel State Medical University, Gomel, Belarus; 2The Republican Research Centre for Radiation Medicine and Human Ecology, Gomel, Belarus; 3Gomel Regional Hospital, Gomel, Belarus; 4Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus.
Introduction: Gestational diabetes mellitus (GDM) has been recognized as a significant risk factor for metabolic syndrome. Emerging evidence suggests that leptin, an adipocyte-derived hormone, may have independent direct effects on both insulin secretion and action, in addition to its well documented effects on appetite and energy expenditure. The aim of this study was to evaluate fasting serum leptin concentration and its association to insulin resistance in women with gestational diabetes mellitus.
Materials and methods: 65 women with GDM and 22 healthy pregnant women (controls) were enrolled. Demographic and clinical data, lipid and carbohydrate metabolism, serum concentration of fasting leptin, insulin, and homeostatic model assessment index were compared and their relationships were analyzed. Metabolic syndrome prevalence was calculated by WHO and NCEP–ATPIII definitions.
Results: The serum leptin level was significantly higher in women with GDM than in the control group (P=0.04). There was significant differences between insulin and homeostatic model assessment index and leptin in women with GDM (r=0.314, P=0.02).
Conclusion: Our data demonstrated that GDM is associated with greater insulin resistance than observed in normal pregnancy and it might be a risk factor for GDM in pregnant women. However, larger prospective cohort studies are needed to confirm the etiologic importance of hyperleptinemia in pregnancy.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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