Endocrine Abstracts

Introduction: Polyglandular autoimmune syndrome type II (PGA-II) is the most common immunoendocrinopathy syndrome, characterized by the obligatory occurrence of Addison disease in combination with thyroid autoimmune diseases and/or type 1 diabetes mellitus. This case report presents coexistence of mosaic Turner syndrome and pituitary micoradenoma in patient with PGA-II.

Case report: A 30-year-old women underwent IVF for four times, with no success (always poor ovarian response, double embryo transfer). Hashimoto’s thyroiditis and subclinical hypothyreoidismus were treated with levothyroxine substitution. Patient’s karyotype testing shown a mosaic monosomy X (46, XX/45, X0), with 5% of analyzed cells caracterized by monosomy X, but no syndrome phenotype characteristics, entered puberty at the time, regular menstrual cycles and no echocardiography dysgenetic ovarian characteristics. NMR sellar region shown microadenoma in the right half. Repeatedly elevated prolactin level in the morning, but preserved circadian rhythm and daily values in the referent range. No adequate cortisol answer in insulin tolerance test, but normal prolactine and GH. In TRH test no paradoxal response. During the last IVF no follicle on folitropine stimulation was found, and for the first time higher FSH value and lower AMH value were found, indicating premature ovarian insuffuciency; antiovarian antibodies were negative excluding immune-mediated process. A year later, menstrual cycles became irregular. Two years later she presented with sings of hypocorticisam (artralgia, hyperpigmentation, fatigue and hypotension) and low corisol level, but normal electrolyte level, hydrocortisone substitution was started. PTH was in referent range. Positive anti GAD and anti IA2 antibodies were demonstrated, oral glucose tolerance test was normal. Patient is now in oocyte donation process.

Conclusions: Oocyte donation may offer solution to women with multiple autoimmune disorder causing infertility.