ECE2014 Poster Presentations Endocrine tumours and neoplasia (99 abstracts)
The value of parathyroid hormone determination in ultrasound-guided fine-needle aspirates (FNA–PTH) for preoperative localization of parathyroid lesions.
Magdalena Kochman 1 , Waldemar Misiorowski 1 , Lucyna Papierska 1 , Elżbieta Stachlewska-Nasfeter 2 , Witold Chudziński 4 & Jarosław Ćwikła 3
1Department of Endocrinology, Medical Centre for Postgraduate Education, Bielański Hospital, Warsaw, Poland; 2Department of Endocrine Oncology and Nuclear Medicine, Maria Sklodowska–Curie Memorial Cancer Center, Institute of Oncology, Warsaw, Poland; 3Department of Radiology, University of Varmia and Masuria, Olsztyn, Poland; 4Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, Warsaw, Poland.
Introduction: Ultrasound imagining of parathyroid lesions is often challenging, as they may be difficult to distinguish from thyroid lesions or enlarged lymph nodes.
Aim: The aim of the study was to assess the value of parathyroid hormone determination in ultrasound-guided fine-needle aspirates-(FNA) in preoperative localization of parathyroid lesions.
Materials and methods: We measured FNA–PTH in 30 consecutive patients with primary hyperparathyroidism referred to our department and qualified for surgery from January 2012 to December 2013. All patients underwent neck ultrasound and biopsy specimens of suspicious lesions were taken by the same physician, blinded to other localization studies results (MIBI scans and CT scans). A positive cutoff value for PTH washout concentration was defined as superior to serum PTH level obtained at the same time.
Results: According to histological examination, elevated FNA–PTH concentration correctly identified all but one parathyroid lesions. Combined ultrasound-FNA–PTH was more specific than combined ultrasound-MIBI scan in identifying parathyroid lesions.
Conclusion: Measurement of FNA–PTH concentration is useful tool for identifying parathyroid gland lesions, especially in patients with concomitant nodular goiter.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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