Endocrine Abstracts

Objectives: Diabetic nephropathy is a common complication of diabetes. It can be a cause of abnormal lipoprotein metabolism and may be had an negative impact on metaboic control in diabetics. The aim of this study was to evaluate the effect of diabetic nephropathy on lipid profiles of adult type 1 diabetics.

Methods: Our study was carried out retrospectively in Istanbul Medeniyet University Goztepe Training and Research Hospital between 2012 and 2013. The cohort composed of 248 type 1 diabetic patients (128 males and 120 females) attending the diabetes outpatient clinic. Mean age was 37.4±11.0 years (range: 17–74). LDL cholesterol, HDL cholesterol, TG, levels, anthropometric parameters, HbAlC, and urinary albumine levels were obained from patients records. Statin user type 1 diabetics are excluded from the study. Data analyzed by SPSS 17.0. Comparisons between different groups were performed by unpaired t-tests. Comparisons across categories were made using x². Correlations between variables of interest were performed by Pearson correlation.

Results: There were 39 (15.7%) patients with albuminurea. 37 patients was user of ACE blocker or ACE receptor blocers. There were no significant difference between normal group and nephropatic group acoordig to LDL cholesterol (111.40±36.78 vs 121.00±43.54 respectively P=0.148). On the other hand there were also no significant difference between two groups neighter HDL cholesterol (56.62±32.54 vs 51.61±12.69 respectively P=0.345) nor tiriglserid levels (106.44±86.19 vs 127.94±88.47) respectively P=0.156). On the other hand in albuminuric group there were a positive corelation between LDL (r=0.679, P=0.000), triglyceride (r=0.685, P=0.000) levels and albumin levels in 24 h urine. This corelation is not valid for normoalbunuric group.

Conclusion: This study showed that LDL and HDL cholesterol, triglyceride levels do not show between albuminuric and normoalbunuric group but the levels of cholesterol show positive corelation in albumin levels in albuminuric group.