Endocrine Abstracts

Introduction: Left ventricular hypertrophy (LVH) in obesity cannot be explained only by increased body mass (BM), BMI, or arterial hypertension (AH). Aim was to investigate possible clinical or hormonal predictors of LVH.

Materials and methods: We examined women before The Programme of Weight Loss. The echocardiography was performed; mass of myocardium of LV (MMLV), relative wall thickness (RWT) and indexed MMLV (IMMLV) by body surface area were calculated. LVH was diagnosed when IMMLV≥95 g/m², increased RWT - RWT≥0.42. Fasting insulin, leptin and adiponectin were measured.

Results: Data of 113 women (age=44.34±11.18 years, BMI=35.00±5.22 kg/m²) were evaluated. 67 women had LVH (59.3%), 56.5% of them had AH (P=0.010). Insulin, leptin and adiponectin did not differ in women with or without LVH. Patients with enlarged RWT had increased levels of leptin (55.14±30.24 vs 42.60±24.17 ng/ml, P=0.041) and decreased levels of adiponectin (10.12±0.56 vs 12.94±0.72 mkg/ml, P=0.050). In multinominal regression age (β=1.67, P=0.005), BM (β=2.63, P=0.004) and mean blood pressure (BP) (β=1.07, P=0.009) were predictors of increased MMLV; age (β=0.83, P=0.006) and mean BP (β=0.56, P=0.007) were also positive predictors of increased IMMLV. In logistic regression age (OR=1.07, P=0.024), BM (OR=1.08, P=0.023), AH (OR=34.7, P=0.038), waist circumference (OR=0.92, P=0.038) and adjusted by AH BMI (OR=0.12, P=0.042) were predictors of LVH, whereas only adiponectin level was a positive predictor of increased RWT (OR=2.80, P=0.039).

Conclusion: Adiponectin and leptin may be also positive predictors of increase of LV mass as age, BM and AH.

Keywords: Left ventricular hypertrophy, adiponectin, leptin.