ECE2014 Poster Presentations Cardiovascular Endocrinology & Lipid Metabolism (41 abstracts)
Isotretinoin effect on osteopontin, hs-CRP, insulin sensitivity and CIMT in acne patients
Ali Saklamaz 1 , Belkis Uyar 2 , Aynur Solak 3 , Muhittin Akyildiz 4 , Berhan Genc 3 , Ayse Gokduman 4 , Murat Yalcin 5 , Halil Aykir 5 & Ozlem Ozenturk Kirgiz 5
1Endocrinology and Metabolism Department, Sifa University, Konak, Izmir, Turkey; 2Dermatology Department, Sifa University, Konak, Izmir, Turkey; 3Radiology Department, Sifa University, Konak, Izmir, Turkey; 4Biochemistry Department, Sifa University, Konak, Izmir, Turkey; 5Internal Medicine Department, Sifa University, Konak, Izmir, Turkey.
Introduction: Isotretinoin (Iso) treatment in acne disease may cause dyslipidemia and increased liver enzymes. Its effects on lipid and glucose metabolism may cause atherogenic complications. The aim of this study was to evaluate carotis intima–media thickness (CIMT), HOMA-IR, and osteopontin (OPN) levels in acne patients on Iso treatment.
Methods: Iso treatment given 21 patients are included in this study. They followed for 4 months. 21 patients with acne were given Iso (0.5–0.8 mg/kg) for 4 months. Blood tests for lipid profile, fasting glucose, liver enzymes, OPN, HOMA-IR, hs-CRP, and CIMT measurements were done before and after Iso treatment. Serum levels of osteopontin, hs-CRP were measured by ELISA and by particule association turbidimetric assay respectively.
Results: Iso treatment significantly caused dyslipidemia, increased CIMT (0.60–0.74 mm; P<0.05), while it non-significantly increased HOMA-IR (0.91–1.87; P>0.05), OPN (4.32–5.44 ng/ml; P>0.05), and hs-CRP (0.08–0.09 mg/dl; P>0.05) levels.
Conclusions: Iso treatment in acne patients increased the risk of atherosclerosis probably by causing dyslipidemia but it also, albeit non-significantly increased OPN, hs-CRP, and HOMA-IR levels.
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Endocrine Abstracts
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