Endocrine Abstracts

Introduction and objective: Recently, a lot of studies associated with high mean platelet level (MPV) in patients with hypo- and hyperthyroidism has reported in medical litherature. But it is not clear whether or not radioactive iodine treatment effect on platelet activity. It is well known that elevated platelet size is associated with its high enzymatic and metabolic activity. Aim of our preliminary study is to determine the platelet size via MPV level in hyperthyroid patients undergoing radioactive iodine ablation treatment.

Patıents and methods: Thirty-four patients with hyperthyroidism treated with a therapeutic dose of ¹³¹I in our endocrinology department between 2009 and 2013 years were included this retrospective study. Patients treated with radioiodine received a single therapeutic dose of ¹³¹I (range 8–15 μCi). Free T₃, free T₄ and TSH levels were performed before and after the RAI ablation treatment. All these parameters were reevaluated at least after 1 year from RAI ablation treatment. All hormonal analyses were performed by chemiluminescence assay. Complete blood count analysis was measured by the automatic hematology analyzer Beckman Coulter LH 750. BMI was calculated by using a formula as weight (kg)/(height (m))².

Results: The mean age in present study population was 42.1±8.4 yeara. In demographic features of patients, mean BMI was 25.8±2.7 kg/m², mean waist circumference was 91.0±9.0 cm. Before RAI treatment the mean free T₃ levels was 4.5±1.6 pg/ml; the mean free T₄ levels was 1.4±0.6 ng/dl; the mean TSH levels was 0.06±0.08 μIU/ml; after RAI treatment, the mean free T₃ levels was 3.07±0.5 pg/ml; the mean free T₄ levels was 1.1±0.2 ng/dl; the mean TSH levels was 1.6±1.3 μIU/ml. The mean MPV levels before the treatment (8.5±1.2 fl) was found increase when compare with (8.0±1.2 fL) (P=0.0001) after the treatment.

Conclucion: Our present study indicated that MPV is a decrease after RAI ablation treatment. A previously study has reported that after 3 weeks of antithyroid drug therapy there was a significant decrease in MPV compared with the pretreatment values in hyperthyroid patients. Our preliminary study is the first notice that RAI therapy may have beneficial effect on MPV levels. Further studies are needed to explain this subject.