ECE2014 Poster Presentations Thyroid (non-cancer) (125 abstracts)
Study of thyroid function during pregnancy in a random population of Northern Greece
Anargyros Kourtis 1 , Eleni Xanthopoulou 1 , Kali Makedou 2 , Aristides Slavakis 3 , Vasileia Mane 3 , Pantelitsa Rakintzi 3 , Dimitrios Delkos 1 & David Rousso 1
1Third Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece; 2Laboratory of Biological Chemistry, Medical Faculty, Aristotle University of Thessaloniki, Thessaloniki, Greece; 3Laboratory of Biochemistry, Hippokratio General Hospita, Thessaloniki, Greece.
It is well established that overt maternal hypothyroidism and subclinical hypothyroidism may be associated with an adverse outcomes for both the mother and offspring. Therefore, maternal hypothyroidism should be early diagnosed and treated.
Aim: The present study was designed in order to investigate thyroid function in the three trimesters of pregnancy, according to the recently updated guidelines.
Materials and methods: One hundred and fifty one (n=151) pregnant women, examined earlier than the 13th week of pregnancy for the first time in the Obstetrics Outpatient Clinic, were included in the study. Pregnant women were followed throughout pregnancy and assessments of TSH, FT4, thyroid antibodies (antiTg and antiTPO) serum levels were carried out at first visit, in the second trimester (13–28 weeks) and in the third trimester (>28th week) of pregnancy. Level of statistical significance was set at P<0.05.
Results: In the first trimester, 20 (13.2%) pregnant women had TSH >2.5 μIU/ml, 20 (13.9%) had FT4 <0.84 ng/dl and 19 (12.6%) had antiTg and/or antiTPO serum levels above normal. Subclinical hypothyroidism (TSH> 2.5 μIU/ml (n=20) and normal FT4 levels) was identified in 14 out of 20 women. Related samples Friedman’s two-way ANOVA revealed that there was a significant increase of mean TSH levels between first and second trimester but non-significant between second and third trimester. Similarly, mean FT4, antiTg and antiTPO levels were decreased significantly between first and second, but non-significantly between second and third trimester.
Conclusions: Given the fact that pregnant women with TSH >2.5 μIU/ml in the first trimester should receive thyroxine to avoid possible complications, and the fact that above 10% of pregnant women of our study had increased TSH levels, most of which had subclinical hypothyroidism, screening for TSH, FT4 and thyroid antibodies is recommended in the beginning of pregnancy.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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