ECE2014 Poster Presentations Thyroid (non-cancer) (125 abstracts)
Interplay between ghrelin, obestatin, leptin and triiodothyronine that possibly regulate energy metabolism during the time of puberty in normal healthy boys
S S R Rizvi 1, , Saba Jannat 1 , Sana Mehboob 1 , Nadia Afzal 1 , Ghazala Shaheen 1 , Azka Falak 1 , A A Naseem 1 , Ghazala kokab 2 , Faheem Tahir 3 & Mazhar Qayyum 1
1Department of Zoology, PMAS Arid Agriculture University, Rawalpindi, Pakistan; 2Chemistry Institute of Biochemistry and Biotechnology, Rawalpindi, Pakistan; 3Department of Reproductive Physiology, National Institute of Health, Islamabad, Pakistan; 4Pakistan Science Foundation, Islamabad, Pakistan.
Ghrelin, a putative signal of insufficient energy stores, increases in fasting states, decreases postprandially, and acts as a potent appetite stimulant increasing food intake. Obestatin affects appetite, food preferences to increase daily caloric intake and weight gain. Leptin regulates body fat mass, food intake and energy expenditure. Triiodothyronine (T3) is a determinant of adiposity, thermogenesis, glucose and lipid metabolism, appetite, food intake, and the oxidation of fatty acids. The present study explored interplay between circulating concentrations of ghrelin, obestatin, leptin and T3 in boys (n=529) between the age of 10 and 20 years. Blood samples were collected and plasma concentrations of ghrelin, obestatin, leptin and T3 were determined using specific ELISA. Data were analyzed using Student’s t-test, ANOVA and Pearson’s correlation. The concentrations of ghrelin significantly increased at 11th year of age, sustained till 13th year, abruptly increased at 14th year markedly decreased till 16th year and significantly augmented to peak concentration at 17th year, and declined at 18th year and maintained at 19th and 20th years. The concentrations of obestatin suddenly augmented at 11th year, increased steadily till 14th year, markedly rose reaching peak concentrations at 17th year, at 18th, 19th and 20th years. The levels of leptin markedly and progressively declined to lowest concentrations at 18th year and significantly increased at 19th and 20th years. The concentrations of T3 progressively and markedly increased to peak concentrations at 17th year, thereafter slightly decreased and sustained at 20th year. The concentrations of ghrelin, obestatin and T3 increased, whereas the levels of leptin decreased during mid puberty. The concentrations of ghrelin were maintained, those of obestain and leptin declined but the concentrations of T3 increased during late puberty/adolescence. The concentrations of ghrelin, obestatin and T3 were positively correlated with one another and negatively correlated with leptin at mid puberty.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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