Endocrine Abstracts

Introduction: Various hematologic disorders have been reported in hypothyroidism. They are resulting from the effect of thyroid hormones regulating the hematopoiesis.

Population and methodology: 100 patients with primary hypothyroidism unsubstituted received a thyroid balance (FT₄, TSH us, and Ac anti-TPO cevicale ultrasound) and hematologic exploration (FNS determination of serum ferritin, TIBC). The blood test was completed according to the results. Patients with hematological history or taking a drug that may sound on hematopoiesis were excluded.

Results: 63% of patients had hematologic abnormalities: 58% anemia, leukopenia 6%, and 8% thrombocytopenia.

Different types of anemia were objective: normocytic normochromic (34.48%), microcytic (48.28%) Macrocytic (17.24%).

Mean hemoglobin, hematocrit and MCV are respectively 10.2±1.18 g/dl 31, 84±3.97% and 78.4±1.14.

The mean values of white blood cells and platelets are – 150 000±20 and 3000±12. The decrease in the number of white blood cells has focused on neutrophils (70%) and lymphocytes (82%).

Although present in both types of hypothyroidism (moderate and deep), hematological disorders are more pronounced in the second (n=38, mean TSH 15±1.2 mU/l, 60.47%) and (n: 62; TSH average 45±1.2, 64.91%) (P: 0.005)

Paraclinical revaluations 3 and 6 months after hormone replacement showed the complete disappearance of leukopenia and persistence of anemia and thrombocytopenia in 7.7 and 5%. They are due to pernicious anemia and idiopathic thrombocytopenia.

Discussion and conclusion: HT regulate hematopoiesis by acting on erythroblast receptors. They stimulate the secretion of erythropoietin and promote terminal differentiation and proliferation of hematopoietic cells. If thyroid disease, hematological disorders must be research systematically.