ECE2014 Poster Presentations Thyroid (non-cancer) (125 abstracts)
Hyperglycaemia in hypothyroidism
Said Azzoug 1 , Farida Chentli 1 , Souad Chellali 2 , Fatma Zohra Boudissa 2 & El Hadj Ahmed Koceir 2
1Endocrinological Department, Bab El Oued Hospital, Algiers; Algeria, 2Biology Department, USTHB University, Algiers, Algeria.
Thyroid hormones disturbances may lead to glucose metabolism abnormalities but little is known about the risk of hyperglycaemia in hypothyroidism.
The aim of our study is to determine the frequency and the predisposing factors to hyperglycaemia in hypothyroidism.
Subjects and methods: It is a retro and prospective study including 425 hypothyroid subjects (383 F/42 M). We search for hyperglycaemia which means fasting glycaemia ≥;1 g/l and/or glycaemia after OGTT ≥1.40 g/l. Thereafter we search for predictive factors of hyperglycaemia in hypothyroidism.
Results: 160 patients (37.6%) had hyperglycaemia. Patients having hyperglycaemia were older (54.4±1.08 vs 45.7±0.8 years), their BMI was higher (31.5±0.53 vs 28.7±0.37 kg/m2), were more frequently hypertensive (54.3 vs 21.5%) and have more familial background of diabetes (36.2 vs 29.8%) than patients with normal glucose metabolism.
Discussion: It is well known that glucose abnormalities are frequent in hyperthyroidism but little is known about the risk of hyperglycaemia in hypothyroidism. Longstanding hypothyroidism may predispose to hyperglycaemia through the development of abdominal obesity and insulin resistance, ageing patients and patients with familial background of diabetes seems to be at higher risk.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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