ECE2014 Poster Presentations Diabetes (epidemiology, pathophysiology) (63 abstracts)
Compensatory increased irisin levels in gestational diabetes mellitus
Tugba Arkan 1 , Mehmet Calan 1 , Dilek Cimrin 1 , Pinar Yesil 2 , Mehmet Asi Oktan 1 , Kemal Aygun 1 & Firat Bayraktar 1
1Dokuz Eylul University, Izmir, Turkey; 2Ege University, Izmir, Turkey.
Context: Irisin, a newly discovered hormone, is secreted by skeletal muscles into circulation. It is proposed to regulate energy homeostasis and hold therapeutic potential in diabetes and obesity.
Objective: We aimed to investigate the association of irisin and uncoupling protein 1 (UCP1) with gestational diabetes mellitus (GDM).
Design and Setting: This was a cross-sectional study conducted in a university hospital.
Participants: A total of 61 pregnant women (30 GDM; 31 non-GDM) along with 41 age-matched non-pregnant controls participated in the study.
Main Outcome Measures: Plasma irisin, serum UCP1, insulin, fasting blood glucose (FBG), high sensitivity C-reactive protein (hs-CRP), and lipids were measured.
Results: Irisin levels were significantly higher and UCP1 levels lower in the GDM group, compared with both the non-GDM and the control groups (P<0.001). Irisin was inversely correlated with UCP1 (r=−0.42, P<0.001) and positively correlated with body mass index (BMI; r=0.25, P=0.008), hemoglobin A1c (r=0.22, P=0.026), homeostasis model assessment of insulin resistance (HOMA-IR; r=0.22, P=0.024), total cholesterol (r=0.39, P<0.001), and triglycerides (r=0.25, P=0.010). UCP1 was inversely correlated with BMI (r=−0.20, P=0.046), HOMA-IR (r=−0.25, P=0.011), total cholesterol (r=−0.27, P=0.006), and triglycerides (r=−0.29, P=0.003). Logistic regression analysis results indicated that irisin levels were not a significant risk factor for developing GDM. On the contrary, lower UCP1 levels were a risk factor independent of the other factors. Multiple regression analysis showed that BMI and UCP1 levels were directly related to irisin levels.
Conclusion: In patients with GDM, irisin signaling might be impaired leading to a compensatory increase in its levels.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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