Endocrine Abstracts

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Pituitary development involves a number of genes encoding signaling molecules and transcription factors. Genetic mutations of any of these factors are implicated in the aetiology of congenital hypopituitarism. The phenotypes of patients with pituitary development disorders might be highly variable depending on the type and severity of deficiencies and the age of diagnosis. A diagnosis of congenital pituitary hormone deficiency must be suspected when other causes of hypopituita...