Endocrine Abstracts

Osteoporosis in children is not just BMD and bisphosphonates. Children are unique in their ability to grow and repair bone tissue. Diagnostics, management and the spectrum of osteoporotic conditions encountered in children are different from adults. Children can have primary osteoporosis which are rare diseases like osteogenesis imperfecta (OI), and secondary osteoporosis resulting from chronic conditions or their treatment. Disorders of the bone minerals calcium and phosphate...

The interaction of RANKL with RANK is critical for the formation and function of bone-resorbing osteoclasts. Denosumab, a fully human MAB against RANKL, is an anti-resorptive drug that acts by preventing RANKL from interacting with RANK on the osteoclast precursor cells. Twice-yearly denosumab treatment is associated with markedly improved bone mineral density (BMD) and cortical and trabecular bone strength, and significantly reduced osteoporotic fracture. In clinical studies,...

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