Endocrine Abstracts

Low-carbohydrate/high-fat diets (LC–HFD) are a popular way of dieting among the general population as several reports in humans indicate that LC–HFD induce weight loss in overweight subjects without caloric restriction and may improve glucose metabolism. However, regarding this type of diet there is also much controversy in scientific literature because clinical studies and data from animal experiments suggest severe side effects and thus warrant caution. Furthermore...

GH receptor-binding protein gene disrupted mice GHR(−/−) are dwarf, obese, insulin sensitive, and long-lived whereas GH transgenic mice are giant, glucose intolerant, lean, and short lived. When challenged with a high-fat (HF) diet, all mice became hyperinsulinemic with similar percent weight gains and increases in percent body fat and size of the epididymal, retroperitoneal, and subcutaneous fat depots. For GH mice, the increase in adipose tissue was relatively sm...

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