ECE2014 Poster Presentations Thyroid (non-cancer) (125 abstracts)
Anti-C1q autoantibodies are linked to autoimmune thyroid disorders in pregnant women.
Hana Vítková 1 , Jan Jiskra 1 , Drahomíra Springer 2 , Zdeňka Límanová 1 , Zdeněk Telička 1 , Jana Bartáková 1 & Eliška Potluková 1
1Third Department of Medicine, First Faculty of Medicine, General University Hospital, Charles University in Prague, Prague, Czech Republic; 2Institute of Clinical Biochemistry and Laboratory Medicine, First Faculty of Medicine, General University Hospital, Charles University in Prague, Prague, Czech Republic.
Introduction: Anti-C1q antibodies have been implicated in the pathogenesis of systemic lupus erythematosus. We have previously shown that anti-C1q antibodies are also linked to autoimmune thyroid disorders (AITD). The aim of this study was to assess the occurrence of anti-C1q antibodies in pregnant women with AITD.
Methods: Serum anti-C1q antibodies were measured during the 9–11th gestational weeks in 103 pregnant women screened positive for AITD, and in 96 of these women after delivery (median 16 months). As controls, 117 pregnant women without AITD were included. Corresponding serum levels of TSH and free thyroxine (FT4) were determined. Autoantibodies against thyreoperoxidase (TPOAb) were assessed only in pregnancy.
Results: Anti-C1q antibodies were found more frequently in TPOAb-positive pregnant women than in TPOAb-negative controls (37 vs 12%; P<0.0001). Among pregnant women with AITD, TSH levels were higher in the subgroup positive for anti-C1q antibodies than in the anti-C1q-negative subgroup (2.41 vs 1.94 mU/l, P=0.01); differences in TPOAb and FT4 were not significant. TSH positively correlated with anti-C1q antibody levels in all pregnant women (r=0.20, P=0.043), as well as in the TPOAb-positive subgroup (r=0.237, P=0.027). Serum levels of anti-C1q antibodies decreased after delivery (12.6 vs 9.4 U/l, P=0.026), and did not correlate with thyroid parameters at this time point. Anti-C1q-positivity during pregnancy was not linked to thyroid dysfunction after delivery.
Conclusions: Anti-C1q antibodies are more prevalent in pregnant women with AITD than in healthy pregnant women, but do not associate with postpartum thyroid function.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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