ECE2014 Poster Presentations Thyroid Cancer (70 abstracts)
Single nucleotide polymorphisms associated with papillary thyroid cancer
Dorota Kula 1 , Kalemba Michal 1 , Handkiewicz-Junak Daria 1 , Puch Zbigniew 1 , Kowalska Malgorzata 1 , Kowal Monika 1 , Tyszkiewicz Tomasz 1 , Cyplinska Renata 1 , Polanska Joanna 2 & Jarzab Barbara 1
1Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland; 2Institute of Automatic Control, Silesian University of Technology, Gliwice, Poland.
Papillary thyroid cancer (PTC) is well known family occurring cancer disease. It is estimated, that ~5% of differentiated thyroid cancers (where PTC is the most frequent) are hereditary. Susceptibility genes are poorly known, however, recently some SNPs located on chromosome 9 in FOXE1 locus (rs965513) and on chromosome 14 (rs944289) close to NKX2-1 locus have been confirmed to be associated with PTC in different populations.
The aim of our study was to analyze the association of four SNPs with PTC in Polish population. Analyzed SNPs were located on chromosome 9 in FOXE1 locus (rs965513, rs1867277, and rs1443434) and on chromosome 14 close to NKX2-1 locus (rs944289).
The whole material consisted of 2244 DNA samples from PTC patients and 1168 controls. rs965513 was analyzed in 833 cases and 845 controls, rs1867277 in 1724 cases and 869 controls, rs1443434 in 1779 cases and 788 controls, and rs944289 in all samples. SNPs were analyzed by allelic discrimination technique (7900HT Fast Real-Time PCR System, and Applied Biosystems).
We observed significant association of all investigated SNPs with PTC. OR values were significantly increased: for rs965513 OR was 1.43 (95% CI: 1.4–2.11, P=2.5×10−7), for rs1867277 was 1.59 (95% CI: 1.33–1.89, P=3.4×10−7), for rs1443434 was 1.53 (95% CI: 1.28–1.84, P=4.4×10−6), and for rs944289 OR was 1.52 (95% CI: 1.26–1.83, P=9.6×10−6).
Conclusion: All analyzed SNPs (rs965513, rs1867277, rs1443434, and rs944289) were significantly associated with papillary thyroid cancer in Polish population.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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