ECE2014 Poster Presentations Obesity (53 abstracts)
Relationship of serum TSH with BMI, weight and HOMA-IR in euthyroid obese subjects
Susana Garrido , Ana Rita Caldas , Teresa Pereira , André Carvalho , Cláudia Amaral , Cláudia Freitas , Rui Carvalho , Fátima Bravo , José Carlos Oliveira & Helena Cardoso
Hospital de Santo António, Centro Hospitalar do Porto, Porto, Portugal.
Introduction: Most obese subjects have a normal thyroid function. Despite that, serum TSH seems to be slightly higher in this population, with a positive correlation with the degree of obesity.
Objective: Evaluation of the relationship of serum TSH with BMI, weight, and HOMA-IR in euthyroid obese subjects
Methods: Three hundred obese subjects attending an Obesity Outpatient Clinic and submitted to bariatric surgery between January 2005 and December 2012 were studied by retrospective evaluation of pre-surgical records (weight, BMI, HOMA-IR, TSH, fasting glucose, and insulin levels). One hundred and thirteen subjects were excluded (history of thyroid disease or TSH levels >4.2 mIU/l, n=45; insufficient data, n=50; other reasons, n=18). Results were analyzed using descriptive statistics, Spearman test for correlation analysis and Kruskal-Wallis test for comparison of the parameters between groups; P-value of <0.05 was considered statistically significant.
Results: One hundred and eighty seven subjects were included in the final analyses (151 females and 36 males). Median age of the patients was 44 (min 20, max 67) and median BMI 43.9 kg/m2 (min 32.0; max. 70.8). Median TSH level was 1.9 mIU/l (min 0.5; max 4.2). There was no correlation between serum TSH and BMI (r=0.041; P=0.577), weight (r=0.074; P=0.314) or HOMA-IR (r=0.060; P=0.409). This lack of association remained when male and female were analyzed separately and when subjects were categorized into quartiles according to BMI, weight, and HOMA-IR.
Conclusion: There was no evidence for an association between serum TSH and BMI, weight, and HOMA-IR in this population of euthyroid obese subjects.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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