ECE2014 Poster Presentations Obesity (53 abstracts)
Worsening of cardiovascular risk with increasing number of components of metabolic syndrome in obese non-diabetic individuals
Bruce Wolffenbuttel , Sandra Slagter , André Van Beek , Helen Lutgers , Jana Van Vliet-Ostaptchouk & Melanie Van der Klauw
University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Introduction: The metabolic syndrome (MetS) is a strong predictor of cardiovascular risk. It is influenced by environmental factors, and its prevalence is high in subjects with obesity.
Design: We assessed differences in glucose- and lipid parameters, and hsCRP and microalbuminuria (MA) in obese subjects with and without metabolic syndrome (MetS) in LifeLines, a population-based study. Included were subjects 18–80 years, with BMI>30 kg/m2. We excluded subjects known to diabetes, with fasting blood glucose (FBG) >7.0 mmol/l, or using statins. MetS was defined according to revised NCEP ATP III criteria.
Results: A total of 9297 individuals (61% women) participated. Their mean age was 46±12 years, median BMI 32.3 kg/m2 (IQR 30.9–34.7). In addition to waist circumference, elevated blood pressure was the most prevalent component (Co) of MetS (60%), while elevated FBG was only present in 21%. There was a gradual and highly significant (P<0.001) increase of FBG, HbA1c and serum total and LDL-cholesterol with increasing number of components of MetS (table). We also observed an increase of MA, a marker of endothelial function and cardiovascular risk, but not of hsCRP.
| No MetS Co | 1 | 2 | 3 | 4+5 | P |
| n | 1809 | 3404 | 2426 | 1658 | |
| Age-yrs | 43±10 | 46±12 | 47±12 | 48±11 | <0.001 |
| FBG mmol/l | 4.9±0.4 | 5.0±0.4 | 5.3±0.5 | 5.6±0.6 | <0.001 |
| HbA1c-% | 5.5±0.3 | 5.6±0.3 | 5.7±0.3 | 5.8±0.4 | <0.001 |
| Tchol mmol/l | 5.0±0.9 | 5.2±1.0 | 5.3±1.0 | 5.5±1.0 | <0.001 |
| HsCRP mg/l | 2.6 (1.2–5.6) | 2.8 (1.3–5.7) | 2.9 (1.4–6.2) | 3.0 (1.5–5.6) | 0.051 |
| MA mg/l | 1.8 (1.1–3.1) | 2.1 (1.2–3.9) | 2.4 (1.3–5.0) | 2.8 (1.5–5.6) | <0.001 |
| Data as mean±S.D. or median (IQR) | |||||
Conclusion: Both glucose- and lipid-related parameters and albuminuria worsen with increasing number of components of MetS, reflecting the increase of cardiovascular risk associated with this syndrome.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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