ECE2014 Poster Presentations Obesity (53 abstracts)
Accumulation of abdominal fat in relation to selected proinflammatory cytokines concentrations in non obese Wrocław inhabitants
Grazyna Bednarek-Tupikowska 1 , Aleksandra Zdrojowy-Welna 1 , Barbara Stachowska 1 , Justyna Kuliczkowska-Plaksej 1 , Magdalena Matczak-Giemza 2 , Eliza Kubicka 1 , Urszula Tworowska-Bardzinska 1 , Andrzej Milewicz 1 & Marek Bolanowski 1
1Department of Endocrinology, Diabetology and Isotope Therapy, Wrocław Medical University, Wroclaw, Poland; 2Lower Silesian Oncology Center, Wroclaw, Poland.
Introduction: Metabolically obese normal weight (MONW) subjects, despite their normal BMI, present metabolic disturbances characteristic of abdominal obesity. One of the reasons might be subclinical inflammation caused by the fat tissue excess. The aim of the study was to asses the association between accumulation of fat (especially abdominal) and concentration of selected proinflammatory cytokines – interleukins (IL-6, IL-18) and C-reactive protein (CRP).
Methods and procedures: The study population consisted of 342 subjects (218 womens, 124 mens; age 20–40 years, BMI <27 kg/m2) recruited from a community center in Wroclaw. The group was divided based on the homeostasis assessment insulin resistance index (HOMA) value: 90 MONW subjects with HOMA >1.69 and 252 subjects as control group. Anthropometric parameters, serum IL-6, IL-18, CRP, glucose, insulin concentrations and insulin sensitivity/resistance indexes were evaluated.
Results: CRP levels were significantly higher (3.26 vs 1.97, P=0.03) in MONW women than in the control group. Serum IL-6, IL-18 levels in males and females did not differ in both groups. IL-6 showed significant correlation with the abdominal to gynoidal fat tissue deposit ratio in women. There was a correlation between the CRP and BMI, WHR, waist circumference, total fat, abdominal fat deposit and abdominal to gynoidal fat deposit ratio in both sexes. In women, a positive correlation between CRP and HOMA, FIRI and negative with QUICKI index was present.
Discussion: Increased accumulation of abdominal adipose tissue in non-obese, young and healthy subjects alike is related to increased CRP levels. This might be one of the causes of accelerated atherosclerosis and its clinical consequences in MONW subjects.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more