Endocrine Abstracts

Aim: To assess changes of metabolic status in children with pituitary insufficiency.

Methods: We examined retrospectively 28 children with pituitary insufficiency in the Endocrinological department of University hospital (Minsk) over 2001–2013 years. Group 1 (G1) - children with multiple acquired pituitary insufficiency (MAPI) after brain tumors treatment (11 children (73.3%) underwent surgical, 4 (26.7%) - combined treatment: surgical and radiation exposure) (n=15; 9.4±0.8 years); Group 2 (G2) - multiple congenital pituitary insufficiency (MCPI) (n=13; 12.2±1.1) (P>0.05). We examined the levels of total cholesterol (TC), triglycerides (Tr), atherogenicity coefficient (AC), ALT, AST, free thyroxin, TSH, cortisol, ACTH, prolactin, FSH, LH, testosterone, estradiol; height and weight.

Results: Growth retardation were observed in 10 (66.6%) children G1 and 13 (100%) G2 (P>005); obesity in 3 (20.0%) children G1 (P<0.05). The levels of TC were increased in 5 (33.3%) patients G1 and 1 (7.7%) - G2 (P<0.05); Tr - 3 (20.0%) children G1 and 1 (7.7%) G2 (P<0.05), AC 3 (20%) G1, 1 (7.7%) G2 (P<0.05). G1 children showed the increasing levels of ALT (3(20%)) and AST (3(20%)) children. Hypothyroidism were diagnosed in 100% in both groups (P>0.05), secondary hypocorticism 11 (73.3%) children G1 and 4 (30.8%) - G2, diabetes insipidus - 12 (91.7%) and 2 (15.4%) (P<0.05), secondary hypogonadism - 3 (20.0%) G1 and 5 (33.3%) G2 (P>0.05), GH deficiency - 8 (66.7%) G1 and 13 (100%) G2 (P>0.05), hyperprolactinemia in 3 (20%) children G1

Conclusions: The development of multiple pituitary insufficiency (hypothyroidism, secondary hypokorticism, GH deficiency, diabetes insipidus, secondary hypogonadism) were noted in all children with multiple acquired pituitary insufficiency. Alterations in metabolic status (hypercholesterolemia, elevated levels of atherogenicity coefficient) were observed in 8 (53.3%) patients with multiple congenital pituitary insufficiency.