ECE2014 Poster Presentations Male reproduction (25 abstracts)
Evaluation of adipocytokine levels and vascular reactivity in hypogonadotropic hypogonadal males
Mazhar Müslüm Tuna 1 , Berçem Ayçiçek Doğan 1 , Ersen Karakılıç 1 , Serhat Işık 1 , Fatma Meriç Yılmaz 2 , Canan Topçuoğlu 2 , Dilek Berker 2 & Serdar Güler 3
1Ankara Numune Training and Researh Hospital Endocrynology Department, Ankara, Turkey; 2Ankara Numune Training and Researh Hospital Biochemistry Department, Ankara, Turkey; 3Hitit University Medical Faculty Endocrynology Department, Çorum, Turkey.
Introduction: Hypogonadism have major affect on urogenital system also have several affect on other systems like cardiovascular and skeletal systems. There are very few study conducted on markers of atherosclerosis such as flow mediated dilatation (%FMD), carotis intima-media thickness(CIMT) and adipocytokine levels in idiopatic hypogonadotropic hypogonadal(IHH) males. The aim of this study was to evaluate this atherosclerotic risk factors in adult IHH male.
Material and method: Study population consisted of 11 treatment naive IHH patients and 15 age-matched healthy male controls). A fasting blood sample was obtained for adrenal androgens, leptin, adiponectin and rezistin. The endothelial function was evaluated according to the flow-mediated vasodilation of the brachial artery (%FMD) and carotis intima-media thickness (CIMT) by high resolution B-mode ultrasound.
Results: Clinical features of the subjects participating in the study are reported in Table 1. No significant differences in age, BMI, systolic and diastolic blood pressure were recorded between two group. Leptin level was significantly higher in group 1, whereas adiponectin and rezistin level were same between two groups.
There was a negative correlatin between total testosteron and carotis intima-media thickness (r=−0.656, P=0.008), and a negative correlation between total testosteron and leptin level (r=−0.794, P<0.001). No correlation was found between leptin and CIMT (P=0.184).
| Group 1 | Group 2 | P | |
| Age (years) | 34.9±8.57 | 29.57±11.84 | 0.21 |
| BMI (kg/m2) | 23.6 | 22.8 | 0.26 |
| Total testosterone (nmol/l) | 0.34 (0.18–1.89) | 5 (4–5.2) | <0.001 |
| Adiponectin (ng/ml) | 4.41 (3.78–6.03) | 5.25 (2.40–5.50) | 0.81 |
| Leptin (ng/ml) | 14.92±9.33 | 4.36±1.71 | 0.01 |
| Rezistin (pg/ml) | 4633±2062.77 | 4058.29±1962.5 | 0.56 |
| CIMT (mm) | 0.80 (0.75–0.90) | 0.55 (0.50–0.68) | 0.02 |
| %FMD | 3.5 ((−0.40) −0.09) | −22.4 ((−0.37) −0.14)) | 0.12 |
Conclusion: Hypogonadal men had higher levels of leptin suggest leptin rezistance. Also had higher CIMT measurement. %FMD measurement were worser in IHH males bu it wasn’t significantly different.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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