ECE2014 Poster Presentations Male reproduction (25 abstracts)
A possible association between circulating concentrations of obestatin, LH, FSH, testosterone and inhibin B during puberty in normal healthy boys
A A Naseem 1 , S S R Rizvi 1, , Ghazala Shaheen 1 , Nadia Perveen 1 , Sana Mehmood 1 , Urooj Anwer 1 , Faheem Tahir 2 & Mazhar Qayyum 2
1Department of Zoology, PMAS Arid Agriculture University, Rawalpindi, Pakistan; 2Department of Reproductive Physiology, National Institute of Health, Islamabad, Pakistan; 3Pakistan Science Foundation, Islamabad, Pakistan.
The G protein coupled receptor of obestatin GPR39 is expressed in pituitary and gonads, indicating its possible role in regulation of pituitary and testicular function. The present study examined a possible association of obestatin with LH, FSH, testosterone, and inhibin B at puberty. Blood samples were collected from 10 to 20 years old boys (n=557) and concentrations of obestatin, LH, FSH, testosterone, and inhibib B were determined using specific ELISA. Data were analyzed using Student’s t-test, ANOVA, and Pearson correlation. The concentrations of obestatin augmented significantly at 11th year, steadily increased reaching peak levels at 17th year and declined at 18th, 19th and 20th year. The concentrations of LH reached a small peak at 12th year, an intermediate peak at 15th year, a highest peak at 18th year. The concentration of testosterone gradually increased till 13th year, increased significantly at 15th year, further increased to peak at 18th year and decreased to slightly low concentrations at 20th year. The levels of FSH increased abruptly at 11th year, progressively increased to a 2nd peak at 15th year, a 3rd peak at 18th year. The concentrations of inhibin B progressively increased to reach highest levels at 14th year and thereafter progressively declined till 20th year. The concentration of obestatin, LH, FSH, testosterone, and inhibin B augmented significantly during mid puberty. Whereas the concentrations of obestatin and inhibin B decreased, the levels of FSH, LH, and testosterone continued to rise during late puberty/adolescent. The concentrations of obestatin, LH, FSH, and testosterone were positively correlated at early and mid puberty, whereas the concentrations of obestatin and inhibin B were positively correlated at all stages of pubertal development. In conclusion, the present study demonstrates a positive correlation between circulating concentrations of obestatin and LH, FSH, testosterone, and inhibin B in boys at mid puberty.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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