ECE2014 Poster Presentations Male reproduction (25 abstracts)
Hypogonadism in aged hospitalized male patients: prevalence and clinical outcome
Pedro Iglesias 1 , Florentino Prado 2 , María Cruz Macías 2 , María Teresa Guerrero 2 , Angélica Muñoz 2 , Elena Ridruejo 2 , Pilar Tajada 3 , Carmen García-Arévalo 3 & Juan José Díez 1
1Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain; 2Department of Geriatrics, Hospital General, Segovia, Spain; 3Department of Biochemistry, Segovia, Spain.
Objective: Male hypogonadism is common in the elderly and has been associated with increased risk of mortality. Our objective has been to assess the prevalence of primary and central hypogonadism in elderly male patients admitted to the hospital because of acute illness. We also evaluated the relationships between gonadal dysfunction and in-hospital mortality.
Patients and methods: 150 male patients, aged ≥65 years, admitted during 2010 and 2011 in our geriatric unit, were studied. Serum concentrations total, bioavailable and free testosterone, as well as of FSH, LH were quantified in every patient. Hypogonadism was defined by the presence of serum testosterone levels lower than 200 ng/dl.
Results: Hypogonadism was found in 80 patients (53.3%). Serum gonadotropin concentrations were elevated in 43.7% of these patients, where as 41.3% of hypogonadic patients showed normal and 15% low gonadotropin concentrations. Respiratory tract infection and congestive heart failure were the main cause of hospitalization in hypogonadal men, whereas acute cerebrovascular disease was the main reason for admission in eugonadal patients. From the 13 patients who died during hospitalization, 12 were hypogonadic. Patients who died showed significantly lower serum levels of total, free and bioavailable testosterone than those found in patients who survived.
Conclusion: Our results show that about half of male patients admitted for acute illness have hypogonadism, mainly of non-hypergonadotropic type. Gonadal hypofunction is significantly related with in-hospital mortality. A low value of serum testosterone may be a predictor for mortality in elderly male patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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