ECE2014 Poster Presentations Female reproduction (54 abstracts)
Metabolic fingerprint of serum in first trimester of healthy pregnancy permits the prediction of macrosomia
Monika Zbucka-Kretowska 1 , Michal Ciborowski 2 , Dorota Bomba-Opon 3 , Miroslaw Wielgos 3 , Robert Brawura-Biskupski-Samaha 3 , Piotr Pierzynski 1 , Maciej Szmitkowski 4 , Slawomir Wolczynski 1 , Danuta Lipinska 5 , Anna Citko 2 , Witold Bauer 2 , Maria Gorska 5 & Adam Kretowski 5
1Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Bialystok, Poland; 2Centre for Clinical Research, Medical University of Bialystok, Bialystok, Poland; 3First Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland; 4Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland; 5Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.
Macrosomia is associated with pregnancy complications and is suggested to predict child’s and mother’s health. High birth weight (>4,000 g) has been associated to the risk of several major chronic diseases in future life including diabetes, cardiovascular disease or cancer. Additionally delivery of a large baby carries a risk of perinatal complications. The aim of this study was to obtain serum fingerprints of healthy pregnant women to identify early biomarkers of macrosomia and to understand the mechanisms leading to abnormal fetal growth not related to mother’s BMI or presence of GDM.
Study was performed on serum samples collected at 12th–14th gestational week from 48 pregnant women (20 with high (HBW) and 28 with normal (NBW) birth weight). Samples were fingerprinted by LC-QTOF-MS and level of adipocyte fatty acid binding protein (A-FABP) enzyme in each sample was measured with ELISA kit. Statistical analysis was performed to find differences between metabolic profiles of women who deliver NBW or HBW neonates. Metabolites were also correlated with the level of A-FABP and birth weight.
We found that low levels of phospholipids, lysophospholipids and monoacylglycerols; low vitamin D3 metabolites but high bilirubin levels were associated to fetal macrosomia at delivery. The level of A-FABP in the serum of the mother (in 12th−14th week of gestation) is positively correlated with the birth weight of the neonate and negatively correlated with the level of serum lipids. Alteration in lipid metabolism during pregnancy put women at risk to develop such diseases like cancer, cardiovascular diseases, type 2 diabetes, or obesity. Enhanced transport of lipids by A-FABP from the mother to the fetus could provoke negative effects on fetal pancreatic β-cells being responsible for future diabetes development in individuals with high birth weight.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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