ECE2014 Poster Presentations Female reproduction (54 abstracts)
Prevalence of metabolic syndrome in obese women with polycystic ovary syndrome
Ivana Bozic Antic 1 , Djuro Macut 1 , Jelica Bjekic-Macut 2 , Danijela Vojnovic Milutinovic 3 , Milan Petakov 1 , Bojana Popovic 1 , Dusan Ilic 1 , Tamara Bogavac 1 , Sanja Ognjanovic 1 , Tatjana Isailovic 1 , Valentina Elezovic 1 & Svetozar Damjanovic 1
1Clinic for Endocrinology, Diabetes and Metabolic Diseases, CCS, Belgrade, Serbia; 2CHC Bezanijska Kosa, Belgrade, Serbia; 3Institute for Biological Investigations ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia.
Introduction: Women with polycystic ovary syndrome (PCOS) have higher prevalence of metabolic syndrome (MS) than healthy women. However, it is still unclear weather this is a consequence of PCOS per se or higher prevalence of obesity in this population. The aim of this study was to determine prevalence of MS in obese women with PCOS.
Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Obesity was defined as BMI ≥25 kg/m2. We evaluated 100 obese women with PCOS (PCOS group: 30.9±3.3 kg/m2; 30.1±2.0 years) and 50 obese, age- and BMI-matched healthy women (control group: 30.4±3.0 kg/m2; 31.0±2.7 years). MS was diagnosed according to NCEP–ATP III criteria. In all subjects blood pressure (BP) and waist circumference (WC) were determined. Blood samples were collected in follicular phase of menstrual cycle for determination of basal glucose, insulin, HDL-cholesterol, triglycerides, uric acid (UA). Homeostatic model assessment (HOMA) was used to determine insulin resistance.
Results: PCOS in comparison to controls had significantly higher WC (93.8±8.0 vs 90.9±9.2 cm; P=0.040), insulin (15.4±8.2 vs 10.7±5.5 mU/l; P<0.001), HOMA (3.7±2.2 vs 2.6±1.3; P=0.001); triglycerides (1.4±0.6 vs 1.0±0.4 mmol/l; P<0.001), UA (299.9±70.7 vs 269.7±48.1 μmol/l; P=0.008) and lower HDL (1.1±0.2 vs 1.2±0.2 mmol/l; P=0.031). There was no difference in BP (P=0.983) and basal glucose (P=0.063) between the groups. MS prevalence was significantly higher in PCOS group in comparison to controls (PCOS: 43/100 (43%); controls 6/50 (12%); P<0.001). Of those PCOS who had MS, three criteria were fulfilled in 32%, four in 10% and all five criteria were fulfilled 1% of PCOS.
Conclusion: In comparison to age and BMI matched healthy women, prevalence of metabolic syndrome defined by NCEP–ATP III criteria was higher in our group of obese women with PCOS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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