ECE2014 Poster Presentations Female reproduction (54 abstracts)
Plasma levels of nesfatin-1 in patients with polycystic ovary syndrome
Emine Binnetoglu , Gökhan Erbag , Meryem Gencer , Hakan Turkon , Mehmet Asik , Fahri Gunes , Hacer Sen , Ahmet Vural & Kubilay Ukinc
Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
Introduction: Polycycstic ovary syndrome (PCOS) is an important disorder in women of reproductive age which is characterised with menstrual dysfunction, anovulation and hyperandrogenism. 5–10% of the female population affected by this syndrome. Nesfatin-1 is a new anorexigenic hormone which is expressed from several regions of hypothalamus and peripheral tissues. Nesfatin-1 is related with obesity, insulin resistance and appetite. We aimed to evaluated the nesfatin-1 levels in patients with PCOS.
Materials and methods: Sixty-five patients (37 patients with PCOS and 28 healthy control subjects) were enrolled in the study. We included newly diagnosed patients with PCOS in our study. Diagnosis of PCOS was based on the 2003 ESHRE/ASRM diagnostic criteria.
Results: The patients with PCOS and controls were similar in terms of mean age BMI, W:H ratio and HOMA–IR index. Plasma nesfatin-1 levels were similar between groups. There was no correlation between plasma nesfatin-1 levels and other parameters.
Conclusion: In conclusion nesfatin-1 may be play important role in glucose metabolism and insulin resistance. In this study due to the absence of insulin resistance in PCOS patients, levels of nesfatin-1 were similar with control group. Nesfatin levels were associated with glucose metabolism, but further studies are needed in this regard.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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