Endocrine Abstracts

We report a case of local recurrence and multiple lymph node and pulmonary metastases of renal carcinoid 1 year after nephrectomy in a 61-year-old woman. Primary renal carcinoid tumor arising from renal parenchyma or renal pelvis is a rare neoplasm. The patient was incidentally found to have a mass lesion in the left kidney and left nephrectomy was performed. Histological examination including immunohistochemical for chromogranin A and synaptophysin studies confirmed the diagnosis of the atypical primary renal carcinoid. Tumor in the present case report was not associated with any other renal diseases. Renal carcinoid is mostly detected incidentally by imaging, and is rarely accompanied by symptoms such as flank pain, hematuria or a palpable mass. During follow-up computed tomography demonstrated a local recurrence and multiple lymph node around the inferior vena cava and pulmonary metastases. After scintigraphy of whole body octreotide theraphy was started. After few months the patient started peptide receptor radionuclide therapy somatostatin analogs labeled with ⁹⁰Y in neuroendocrine tumors (NETs). The administered activity of ⁹⁰Y-DOTATATE to the patient was based on 7.4 GBq/m2 body surface area in three cycles, with amino acid infusion for nephroprotection.In presented patient we did not get stabilization of disease and in the middle of the 2013 year she died. Combinations of octreotide with other targeted therapies may improve patient outcomes. Renal carcinoid tumor is a rare neoplasm, early recogniction of disease may help in increasing time to progression.