ECE2014 Poster Presentations Endocrine tumours and neoplasia (99 abstracts)
Epidemiology of gastro-entero-pancreatic neuroendocrine tumors in Krakow and Krakow district area
Malgorzata Trofimiuk-Müldner 1, , Ewelina Lewkowicz 1 , Dorota Pach 1, , Agnieszka Kieltyka 3 , Agnieszka Stefanska 2 , Anna Sowa-Staszczak 2 , Aleksandra Gilis-Januszewska 1, & Alicja Hubalewska-Dydejczyk 1,
1Chair and Department of Endocrinology, Medical College, Jagiellonian University, Krakow, Poland; 2Department of Endocrinology, University Hospital in Krakow, Krakow, Poland; 3Chair of Epidemiology and Preventive Medicine, Medical College, Jagiellonian University, Krakow, Poland.
Cancer registers are important tools in improving the knowledge of epidemiology of rare malignancies, such as gastro-entero-pancreatic neuroendocrine tumors.
Aim: To assess the epidemiology of GEPNETs in Krakow and Krakow district area between January 2007 and December 2011.
Material and methods: To assess the epidemiology of GEPNETs in Krakow area a register was created, based on independent sources of information. 88 patients (49 females and 39 males) aged 59±17 years diagnosed with GEPNETs were included in further analysis. 75% of them were followed in the Endocrinology Department, University Hospital in Krakow. The following parameters were assessed: primary tumor localization, grading (WHO), staging (AJCC/UICC), distant metastases at diagnosis, and standardized GEPNET incidence rate.
Results: The most frequent primary localization of GEPNETs was small intestine (20%), followed by appendix (18%), pancreas (16%), stomach (16%), rectum (15%). Well differentiated GEPNETs prevailed (NET G1 constituted 64% of the group, NET G2 28%, and NEC 8%). Most of the tumors (63%) were diagnosed at stage I according to AJCC/UICC. Distant metastases were found at diagnosis in 31% of patients (to regional lymph nodes in 25% and distant in 18% of patients). Metastases were most frequently observed in NETs of colon (67%), whereas none of the appendiceal NETs was disseminated at diagnosis. The standardized incidence rates of GEPNETs in Krakow and Krakow district area ranged from 1.5 to 2.7 cases/100 000 persons per year, an average of 2.1/100 000 persons per year. The highest incidence was noted in the oldest patients (4.8/100 000 persons per year in subjects aged 60 years and older). No statistically important trend in GEPNETs incidence between 2007 and 2011 was noted.
Conclusions: GEPNET incidence in Krakow and Krakow district area is similar to the incidence observed in most European countries. Cancer register was proved to be important tool in evaluation of GEPNET epidemiology.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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