ECE2014 Poster Presentations Endocrine disruptors (12 abstracts)
The potential role of bisphenol A in the pathogenesis of polycystic ovary syndrome
Aleksandra Rutkowska 1 , Kamila Wilczewska 2 , Lukasz Laczmanski 3 , Justyna Kuliczkowska 3 , Agnieszka Lenarcik 3 , Anna Trzmiel-Bira 3 , Anna Brona 3 , Monika Kuligowska-Jakubowska 1 , Aleksandra Konieczna 1 , Agata Kot-Wasik 2 , Andrzej Wasik 2 , Andrzej Milewicz 3 , Jacek Namiesnik 2 & Dominik Rachon 1
1Medical University of Gdansk, Gdansk, Poland; 2Technical Univerisity of Gdansk, Gdansk, Poland; 3Medical University of Wrocław, Wrocław, Poland.
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, that lead to infertility, type 2 diabetes and coronary heart disease.
Bisphenol A (BPA) is one of the most abundant chemicals produced worldwide and is used as a plasticizer in daily life. Nowadays it is also well know that it can interact with estrogen receptors, androgen receptors and peroxisome proliferator-activated receptors γ (PPARγ). Therefore, the aim of this study was to identify the potential role of BPA in the pathogenesis of PCOS which is the most common endocrinopathy in premenopausal women.
In total 137 women were studied. Sixty-six (mean age 24.5±3.66) were diagnosed with PCOS according to the ESHRE/ASRME (Rotterdam Criteria) consensus. The control group consisted of 71 women (mean age 28.4±4.22) without PCOS. Serum levels of prolactin (PRL), 17OH-progesterone, total testosterone, DHEA-S, insulin and sex hormone-binding globulin (SHGB) were measured. BPA concentrations were analysed in all women’s sera using HPLC method combined with mass spectrometry (HPLC-MS/MS analysis, The Agilent 1200 HPLC system). The results of the analysis have pointed to the higher levels of BPA in the sera of women with PCOS in comparison with healthy controls (median: 3.18 vs 1.73 ng/ml, P=0.05). There has been a positive correlation between the serum concentration of BPA and total testosterone level (P=0.004, R=0.56). There were no correlations between serum BPA concentrations and waist circumference, BMI and serum PRL, DHEA-S, insulin.
These results confirmed the hypothesis of higher levels of BPA in PCOS women, that can exacerbate the androgen production.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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