ECE2014 Poster Presentations Diabetes (epidemiology, pathophysiology) (63 abstracts)
1Department of Endocrinology, Puerta del Mar Hospital, Cádiz, Spain, 2Department of Endocrinology, Puerto Real Hospital, Cádiz, Spain, 3Puerta del Mar Hospital Investigation Unit, Cádiz, Spain.
Objectives: To evaluate the prevalence of blood pressure alterations with ambulatory blood pressure monitoring (ABPM) and its association with proinflammatory cytokines (IL-6 and VEGFα) in normotensive and normoalbuminuric patients with type 1 diabetes (TDM1).
Patients and methods: Cross-sectional study including normotensive and normoalbuminuric patients with TDM1. Altered ABPM was considered when: 1) Mean systolic pressure (sBP) was greater than 130 mmHg in the 24 h and daytime periods and greater than 120 mmHg in the night-time period and/or mean diastolic pressure (dBP) greater than 80 or 70 mmHg in the same periods respectively, and/or 2) More than 50% of the readings were higher than the defined previous criteria, and/or 3) Nocturnal fall in either sBP or dBP was lower than 10% (non-dippers). Serum cytokines levels, including IL-6 and VEGF-α, were measured using Procarta® Immunoassays (Affymetrix).
Results: Eighty-five type 1 diabetic patients (55% women) aged 27.9±6.1 years with a disease duration of 12.3±6.5 years. 32% presented mean sBP or dBP altered during daytime, 32% more than 50% of pathological readings during daytime and 41.6% (n:36) were non-dippers. Significant correlation was detected between IL-6 and 24 h dBP (r: 0.17, P: 0.02), 50% of 24 h dBP high (r: 0.15, P: 0.04) and daytime dBP (r: 0.16, P: 0.03). There was also a statistically significant correlation between VEGFα and 24 h sBP (r: 0.19, P: 0.006), 24 h dBP (r: 0.24, P: 0.002), 50% of 24 h sBP (r: 0.2, P: 0.009), 50% of 24 h dBP (r: 0.21, P: 0.06) and daytime sBP (r: 0.22, P: 0.005). Mean values of both cytokines did not differ between dipper and non dipper patients.
Conclusion: Altered ABPM is prevalent in normotensive and normoalbuminuric patients with type 1 diabetes and related to proinflammatory cytokines. Prospective studies should evaluate if proinflammatory cytokines play a role in hypertension development in this type of patients.