ECE2014 Poster Presentations Diabetes complications (59 abstracts)
Prevalence and risk factors of prolonged QTc interval in type 2 diabetic patients; impact of the type of treatment and quality of glycemic control
Vladan Ninkovic 1 , Milan Dobric 2, , Djordje Jakovljevic 4, , Srdjan Ninkovic 6, , Goran Bubanja 1 , Vladimir Miloradovic 6, , Dragana Zivojinovic 1 , Marijana Babic 1 , Bratislav Milovanovic 1 & Vojislav Giga 2,
1National Educational Centre for Diabetes Merkur, Vrnjacka Banja, Serbia; 2Clinic of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia; 3Medical School, University of Belgrade, Belgrade, Serbia; 4Institute for Ageing and Health, Newcastle upon Tyne, UK; 5Medical School, Newcastle University, Newcastle upon Tyne, UK; 6Clinical Centre Kragujevac, Kragujevac, Serbia, 7Medical School, University of Kragujevac, Kragujevac, Serbia.
Introduction: The aim of this study was to assess the prevalence and predictors of prolonged QTc interval in patients with type 2 diabetes (T2D).
Methods: This study included 501 consecutive T2D patients (277 males, age 60.4±8.1 years) treated in National Educational Centre for Diabetes, ‘Merkur’, Vrnjacka Banja, from September 2011 to July 2012. We analysed baseline clinical and laboratory data including: age, gender, duration of diabetes, BMI, presence of coronary artery disease (CAD), presence of polyneuropathy, type of treatment, renal function, and the presence of traditional risk factors for CAD. In all patients 6–8 blood samples were taken within 24 h and following parametres of glycoregulation were analysed: fasting blood glucose (FBG), mean blood glucose (MBG), and mean amplitude of glucose excursion (MAGE), as well as HbA1c. In baseline ECG corrected QT interval (QTc) was measured, considering QTc>440 ms as prolonged, and QTc>500 ms as significantly prolonged.
Results: Prolonged QTc (>440 ms) was present in 44% of our patients, however, prolongation of QTc>500 ms was observed in only 2% of patients. QTc duration >440 ms was associated in univariable analysis with age, female gender, treatment with sulfonylurea, and different parametres of glycemic control (HbA1c, FBG, MBG, and MAGE) as well as with the history of CAD and presence of diabetic polyneuropathy. However, MBG (B=2.192, P<0.001), female gender (B=8.844, P<0.001), history of CAD (B=8.636, P=0.001), and treatment with sulfonylurea (B=5.198, P=0.027) remained independently associated with QTc>440 ms in multivariable analysis. On the other hand, QTc>500 ms was independently related only to the history of CAD and MBG (OR=12.145, 95% CI 1.818–81.146 and OR=1.457, 95% CI 1.154–1.840 respectively, P<0.001 for both).
Conclusions: QTc>440 ms was highly prevalent (44%) in our T2D patients, with only minority of them (2%) exhibiting QTc prolongation over 500 ms that was independently related to the mean blood glucose and the history of CAD.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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