ECE2014 Poster Presentations Diabetes complications (59 abstracts)
Analysis of diabetic retinopathy risk factors in type 2 diabetes patients
Djordje Popovic 1 , Milena Mitrovic 1 , Dragan Tesic 1 , Jovanka Novakovic-Paro 1 , Dusan Tomic 1 , Tijana Icin 1 , Bojan Vukovic 2 , Milica Medic-Stojanoska 1 & Branka Kovacev-Zavisic 1
1Clinic for Endocrinology, Diabetes and Metabolic Disorders, Medical Faculty, Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Serbia; 2Medical Faculty, Emergency Center, Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Serbia.
Introduction: Diabetic retinopathy screening is the most accessible method of visualization of the affected small blood vessels in diabetic patients. Diabetic retinopathy is associated with age of patients, duration of diabetes, male sex, poor blood glucose control, central obesity, arterial hypertension, increased proteinuria, chronic inflammation and lipid disorders. Our study aims to compare type 2 diabetes patients with and without developed diabetic retinopathy regarding traditional culprits for diabetic retinopathy development and also to analyze differences in therapy modules between two mentioned groups.
Methods/design: Cross-sectional study included 140 type 2 diabetes patients. Patient’s general information were noted, anthropometrical measurements (BMI, waist circumference (WC) and arterial tension) were conducted, blood was sampled for glucose, lipid and lipoprotein metabolism parameters (HbA1c, total, LDL and HDL cholesterol and triglycerides) and fibrinogen, and 24 h urine portion was sampled for proteinuria measurement. Classical fundoscopy was performed in all patients. In statistical analyzes we used mean values, proportions, t-test, test of proportions and multivariate analysis.
Results: In group with developed diabetic retinopathy there were 74 patients and more often they were males (P=0.0218). They were older (P=0.0009) and had longer duration of diabetes (P=0.0002). WC was significantly higher in this group (P=0.0018), and they had higher levels of proteinuria (P=0.0018). As far for therapy modules, these patients were rarely on oral therapy only (P<0.0001), they were less frequently on sulphonylureas (P=0.0030) and more often had insulin in therapy (P<0.0001). Multivariate analysis stands out male sex (P=0.0071), age (P=0.0029), WC (P=0.0051), proteinuria (0.0077) and solely oral therapy (P<0.0001).
Conclusion: Our type 2 diabetes patients with diabetic retinopathy are more often males. They are older, more centrally obese, have higher proteinuria and more frequently are on insulin therapy than patients without this complication which is mostly in accordance with other literature on the same topic.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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