Endocrine Abstracts

The aim of the work was to assess the dynamics of rates of carbohydrate metabolism in DM1 in young persons.

Materials and methods: The study of daily dynamics of glucose was conducted by Continuous Glucose Monitoring System. For the analysis of continuous glycaemic curve there was conducted the computation of risk index (RI) of hypoglycemia and hyperglycemia during the study period.

There were examined 162 patients with DM1. First group with adequate control DM1, HbA1c≤7.5% (n=38), which is 23% and second group with inadequate control, HbA1c>7.5% (n=124), which is 77% of the total number of examined persons. Groups are comparable by average age (28.59±7.10 years), duration of DM1 (10.46±7.28 years), BMI (24.12±3.62 kg/m²).

Results: Adequate control of DM1 was only in 23% of examined patients, in 77% there has been noticed decompensation of DM1 (P<0.05). In the group with HbA1c>7.5% there has been noticed decompensation of DM1 due posthypoglycemic hyperglycemia (RI of hypoglycemia 5.00 (1.60; 9.20), RI of hyperglycemia 16.24 (10.45; 20.60)). In both groups RI of hypoglycemia exceeded 4.5 (group with HbA1c≤7.5% 5.60 (3.00; 10.50), group with HbA1c>7.5% 5.00 (1.60; 9.20)), which indicate a high risk of development of hypoglycemic reactions. In the group with adequate control hypoglycemic episodes have been registered in 82% of the patients and only 18% didn’t have them (P< 0.001).

Conclusion: In 77% of the examined patients with DM1 there have not been achieved target values of compensation, which is approved by the increased value of RI hypo-and hyperglycemia. Decompensation of DM1 is caused by posthypoglycemic hyperglycemia.