Endocrine Abstracts

Study evaluates the impact of glycemia on the parameters of night’s sleep for patients with decompensated type 1 diabetes mellitus (T1DM).Materials and methods: A total of 21 cases with T1DM (HBA1C 8.5%). The monitoring of the average daily glycemia was performed through ‘SGMSGold Medtronik’ (USA) with estimation of average level of glucose (ALG). Patients divided into groups: group A – 10 patients with A...

Thyroid hormone action defects (THADs) are caused by the defective action of thyroid hormones (THs) through their receptors (TRs). TRs variants (TRα1 or TRβ) are associated with several defects, which depend mainly on the tissue-specific expression of the defective-receptor. One of the most striking manifestations is the deregulation of the hypothalamus–pituitary–thyroid axis (HPT); patients with TRα1-mutations show normal thyroid volume, low T4/T3 and...

Introduction: Gonadal dysgenesis (GD) is a congenital disorder which results in defective development of gonads. GD may be due to mutation(s) in any of the genes involved in gonadal development and differentiation. Here we present clinical and molecular profile (SRY and SOX9 gene) of patients with GD at our hospital.Methodology: Detailed clinical examination, karyotyping and molecular analysis of patients was done for SRY and SOX9 gene....

The insulin signalling system including the insulin receptor tyrosine kinase (IRTK) is evolutionarily ancient. The Drosophila Melanogaster genome contains seven genes for insulin-like peptides (ILPs) that are expressed in neurosecretory cells in a highly tissue- and stage-specific pattern, DILP1–7. There is however only one IRTK (dIR). This system is important in the regulation of metabolism, growth, reproduction and lifespan. We reported in 2011 the crystal stru...

Introduction: Combined pituitary hormone deficiency (CPHD) results in deficit of growth hormone and coexisting failure of synthesis or excretion at least another pituitary hormone. Transcription factors controlling expression of genes required for pituitary organogenesis are orchestrating entire development process and certain cell lineages differentiation, contributing therefore significantly to CPHD pathogenesis with childhood onset.Aims: The purpose o...

Objectives: GH plays a crucial role in the regulation of metabolism of human cells. Nevertheless, a direct influence of this hormone on the proliferation, maturation and differentiation of human early hematopoietic stem/progenitor cells (HSPCs) has not been investigated thoroughly. Moreover, certain deviations of hematological parameters, such as anemia or leucopenia, are commonly observed in patients with growth hormone deficiency (GHD) syndrome, which might be substantially ...