ECE2014 Poster Presentations Clinical case reports Thyroid/Others (72 abstracts)
The coexistence of anaplastic thyroid carcinoma and papillary thyroid carcinoma: two case reports
Husniye Baser 1 , Mina Gulfem Kaya 1 , Sefika Burcak Polat 1 , Ersin Gurkan Dumlu 2 , Canan Altunkaya 3 , Mehmet Kilic 2 , Reyhan Ersoy 4 & Bekir Cakir 4
1Department of Endocrinology and Metabolism, Ataturk Education and Research Hospital, Ankara; Turkey; 2Department of General Surgery, Ataturk Education and Research Hospital, Ankara, Turkey; 3Department of Pathology, Ataturk Education and Research Hospital, Ankara, Turkey; 4Department of Endocrinology and Metabolism, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
Introduction: Anaplastic thyroid carcinomas (ATCs) are sometimes accompanied by well-differentiated carcinomas (WDCs), and ATCs have been speculated to be dedifferentiated from the preexisting or coexisting WDCs. We will present two cases determined with both ATC and papillary thyroid carcinoma (PTC.)
Case 1: A 82-year-old woman was investigated due to a painful neck mass. Thyroid function tests were normal. Thyroid ultrasonography revealed isohypoechoic nodules in sizes of 45 and 13.5 mm in right lobe and an isoechoic nodule in size of 11.3 mm in left lobe. Fine-needle aspiration biopsy (FNAB) was performed, and PTC was detected in both nodules on the right. Bilateral total thyroidectomy was performed, and in pathological investigation, the nodule of 45 mm in the right lobe was seen to be an ATC including regions of classical variant PTC. Additionally, the pathology of the nodule of 13.5 mm in the right lobe was consistent with classical variant PTC. PET/CT revealed the involvements of increased 18-FDG consistent with metastasis, and due to the metastatic condition in the case, radiotherapy was performed.
Case 2: A 62-year-old male presented to our clinic complaining of a neck lump and dysphagia. Physical examination revealed 4 cm mass and cervical lymph nodes on the left side of the neck. Thyroid function tests were normal and thyroid ultrasonography revealed hypoechoic nodule in sizes of 41 mm in the left lobe. Two FNABs were reported as nondiagnostic. Bilateral total thyroidectomy and left lymph node dissection were performed. The postoperative pathology report was a 3 cm ATC in the left lobe and a 5 mm PTC in the right lobe. He was given radiotherapy.
Conclusion: PTC followed by poorly differentiated and follicular carcinoma are most frequently cited to coexist or as precursors of ATC. The early diagnosis of thyroid carcinoma results in a decrease of the incidence of ATC.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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