ECE2014 Poster Presentations Cardiovascular Endocrinology & Lipid Metabolism (41 abstracts)
eNOS, p22 phox, CETP and ERα gene polymorphisms related to metabolic–endocrine parameters in postmenopausal women with metabolic syndrome: a population based study
Olga Ianas 1 , Dana Manda 1 , Susana Vladoiu 1 , Oana Popa 1 , Roxana Rosca 1, , Sabina Oros 1 , Marcela Covic 3 , Constantina Heltianu 4 , Anca Sima 4 , Lorand Savu 5 & Mihaela Giurcaneanu 1
1‘C.I. Parhon’ National Institute of Endocrinology, Bucharest, Romania; 2University of Medicine and Farmacy ‘Carol Davila’, Bucharest, Romania; 3‘Ana Aslan’ National Institute of Geriatry and Gerontology, Bucharest, Romania; 4‘N. Simionescu’ Institute of Cellular and Molecular Biology, Bucharest, Romania; 5Genetic Lab SRL, Bucharest, Romania.
Objective: We previously found an association between eNOS(G894T) polymorphism and components of metabolic syndrome (MetS); thus, we investigated the metabolic–endocrine changes in postmenopausal women with incipient MetS and the interaction with the polymorphisms of eNOS-G894T, p22phox-930 A/G, CETP TaqIB and ESR1 (PvuII and XbaI) genes.
Methods: postmenopausal women aged between 60 and 80 years from a population-based study were classified into the two groups, non-MetS (212) and incipient MetS (68). Clinical, anthropometric and endocrine–metabolic parameters were measured. A total of five single nucleotide polymorphisms were determined and tested for interacting with these parameters.
Results: The weight, waist circumference, blood pressure, WBC, uric acid, LDL-C, apolipoprotein B, triglycerides, fasting glucose, insulin, HOMA-IR, TC:HDL-C ratio, apoB:apoA-I ratio were higher in MetS group (P<0.02). The significant high levels of E2, T3, GHBP, PTH, E2:E1 ratio and low levels of cortisol, SHBG, FSH, LH, IGFBP1, cortisol:DHEA ratio were also evaluated in MetS group. Most of biochemical variables are normal range in both groups except glucose, triglyceride, LDL-C, apo B that are in the high borderline range in MetS group.
Testing of Hardy–Weinberg equilibrium in genetic association studies showed significant differences in allelic distribution of p22phox gene (P=0.033) and in distribution of XbaI ESR1 genotypes (P=0.021). Significant associations were detected between gene SNPs and metabolic–endocrine changes. In MetS group the carriers of TT (eNOS-G894T) genotype had higher levels of blood pressure, glucose (P<0.02), GG (p22phox A/G) had higher levels of BMI, VSH, apoB:apoA ratio (P<0.03), B2B2 (CETP B1/B2) had higher levels of TG, TG:C-HDL ratio (P<0.03). CC (PvuII) and GG (XbaI-ER1) genotypes showed higher levels of glucose (P< 0.002).
Conclusions: The results show an interaction between the studied polymorphisms and the endocrine-metabolic changes in MetS pathogenesis. The elevated values of TC:HDL-C and apoB:apoA-I ratios could be risk indicators for calculation cardiovascular risk of MetS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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