Endocrine Abstracts

Aim: The aim of this study was to evaluate metabolic abnormalities in young adults getting treatments of acute lymphoblastic leukemia (ALL) and brain tumors (BT) in their childhood.

Methods: We examined 50 patients in two groups. The group-1: 18 ALL-survivors (nine women and nine men). All of them received cranial irradiation in dose up to 18 Gy and chemotherapy. In group-2: 32 BT-survivors (14 women and 18 men) were included. All patients received craniospinal irradiation up to 36 Gy and boost to the tumor up to 55 Gy and chemotherapy. The median age was 20.5 (19;23) and 20 (18;22) age at the time of treatment – 7.5 (5;9) and 12 (9;15), follow-up period was 13 years (12;16) and 5 years (2;10) respectively. Metabolic profile was examined.

Results: In the 1st group: four patients had dyslipidemia: elevation of LDL-C (n=2) and TG (n=2). OGTT was performed in 12 patients, one woman had FPG=6.2 mmol/l in combination with obesity (BMI=49.1 kg/m²). Three patients had obesity. HOMA-index >2.5 was in seven patients. The age at the time of observation was negatively correlated with GH (r=−0.723114, P=0.007872). There were no significant differences in level of metabolic parameters between two groups.

In the 2nd group: we registered elevation of LDL-C (>3.4 mmol/l) in seven patients, both LDL-C and triglycerides (TG) (>1.2 mmol/l) in six. 12 of them had GH-deficiency, diagnosed with insulin tolerance test. OGTT was performed in 13 patients: FPG=6.1 mmol/l was found in one patient. The median of BMI – 19 (17;21.8). The BMI correlated with TG (r=0.4, P=0.02).

Conclusions: In ALL survivors elevated level of LDL-C and TG was diagnosed in 11.1%. 16% ALL survivors had obesity. BT survivors showed elevated level of LDL-C in 22.5%, increased of LDL-C and TG in 19.4%. There were no abnormalities in carbohydrate metabolism.