Endocrine Abstracts

Aim: The aim of our study is to assess the efficacy of a lifestyle modification including altered diet composition and physical activity in preventing diabetes mellitus type 2 (DM2) in individuals with impaired glucose tolerance and impaired fasting glucose (IGT/IFG) and influence it on changes serum leptin levels.

Materials and methods: The study included 327 patients with IGT/IFG (68 m, 258 f) 25-65 years. Patients were divided into two groups matched by sex, age, weight, and BMI. Research group included 183 patients (32 m, 150 f) who received and carried out individual recommendations of a balanced diet and physical activity. Control group included 144 patients (36 m, 108 f) who did not lifestyle modification. Related to fasting leptin (FL) concentrations by sensitive ELISA.

Results: Patients of the research group demonstrated reduction of body weight (P<0.01). They had positive dynamics of FPG and 2-h PG concentrations also (P<0.001). Persons of the control group had significant increase in weight and BMI and FPG and 2-h PG concentrations elevated (P<0.05). The main novel finding was that median serum leptin in research group decreased on −23.9% (P<0.01) and increased in control group on +27.6% (P<0.01) among subjects with IGT. Among patients of the research group was a reduction of new care DM 2 by 11.9% and an increase in the control group by 35.1%.

Conclusion: Thereby, lifestyle modifications lead to reduction not only fasting plasma glucose, postprandial glucose concentrations but and fasting leptin concentrations in individuals with IGT/IFG.