ECE2014 Poster Presentations Cardiovascular Endocrinology & Lipid Metabolism (41 abstracts)
Osteopontin, hs-CRP levels in gestational diabetes mellitus
Ali Saklamaz 1 , Muhittin Akyildiz 3 , Esin Celik 2 , Mine Genc 2 , Berrin Korkut 2 , Murat Yalcin 4 , Halil Aykir 4 & Ozlem Ozenturk Kirgiz 4
1Endocrinology and Metabolism Department, Sifa University, Konak, Izmir, Turkey; 2Obstretrics and Gynecology Department, Sifa University, Konak, Izmir, Turkey; 3Biochemistry Department, Sifa University, Konak, Izmir, Turkey; 4Internal Medicine Department, Sifa University, Konak, Izmir, Turkey.
Introduction: Gestational diabetes mellitus (GDM) is a sort of temporary carbonhydrate intolerance in pregnancy. GDM leads to a variety of risks for the fetus and the mother during pregnancy. Mothers who had GDM during their pregnancy have high risk of caesarean section and pre-eclampsia. Also there are risks of macrosomia, neonatal hypoglycemia and hyperbilirubinemia for the fetuses of these mothers. Cardiovascular disorders, hypertension, dyslipidemia and metabolic syndrome are the other diseases that can develop in years after GDM. In the literature, OPN is known to have an important role in the development of atherosclerosis, vascular calcification and remodeling. The aim of this study was to evaluate osteopontin (OPN) and high sensitive CRP (hs-CRP) levels in GDM patients.
Methods: 33 patients with GDM and 26 control patients pregnant were included in this study. Blood tests for lipid profile, fasting glucose, oral glucose tolerance test, OPN, HOMA-IR, hs-CRP were done at nearly 24th gestational week. Serum levels of OPN were measured by ELISAs, and serum hs-CRP levels were measured by particule association turbidometric assay.
Results: The gestational week, age, BMI of two groups were similar (P>0.05). The GDM group had significantly higher fasting glucose, prandial (first and second h) glucose, HbA1c levels than the control group. Fasting insulin, HOMA-IR levels were higher in the GDM group than the control group but the difference was not significant. The lipid profiles of two groups were not significantly different. The OPN levels were 3.4 (2) ng/ml in the GDM group and 3.05 (1.6) ng/ml in the control group (P<0.05). The hs-CRP levels were also significantly higher in the GDM group compared with the control group (0.85 (0.7) vs 0.4 (0.3), P<0.05).
Conclusion: OPN and hs-CRP levels were significantly increased in GDM patients.
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Endocrine Abstracts
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