Endocrine Abstracts

Vitamin D and calcium are necessary for proper modelling and remodelling of osseous tissue and optimal bone mass depends on their appropriate supplementation.

Aim of study, materials and methods: The goal of the study was an evaluation of serum vitamin D concentrations (vit. D) in 106 healthy women, aged 20–30 years plus a monthly evaluation – for 3 months – of the effects of calcium (500 mg) and vit. D (1500 IU) administration in women with baseline values of vit. D <20 ng/ml (Group 1) plus the effects of 800 IU/day dose in women with the baseline value of D >20 ng/ml (Group 2). Additionally, calcium and PTH concentrations were assessed at the study onset and after the 3-month supplementation.

Results: The mean vit. D concentration in entire study group was 16.55 ng/ml, being 12.6 ng/ml in the Group 1 and 25.23 ng/ml in the Group 2. In the course of vit. D administration, its concentration increased statistically significantly, both in the entire group and in the subgroups, at all time points vs the study onset (P<0.001). Moreover, the concentration increase was statistically significant after 2 and 3 months, both in the entire group and in the Group 1. Similarly, in the Group 2, the vit. D concentration was systematically rising in the course of the observation but the statistically significant increase was noted vs. the baseline point. Although there were no differences in calcium concentration after the 3 months, a statistically significant drop of PTH (P<0.05) was recorded in the entire population and in the Group 1.

Conclusions: A moderate deficit of vit. D was observed in the studied population of young women. A supplementation with calcium plus vitamin D brought about an increase of vitamin D concentration already in the 1st month of administration. The optimal concentration of >30 ng/ml was achieved in the Group 1 after 3 months of vitamin D administration in the 1500 IU/day dose.

The study was supported by Axellus LLC (Poland).