Endocrine Abstracts

Currently relationship between the decrease in vitamin D (VD) levels and the formation of bone pathology has established. The presence of certain VD receptor (VDR) polymorphisms has been suggested to be associated with the serum VD. Therefore, the aim of study was to assess the association between VDR single nucleotide polymorphisms (SNPs) in type 1 diabetic patients and serum VD.

Materials and methods: We studied 66 type 1 diabetic (T1D) patients (28 men and 38 women; mean age 31.23±8.41; duration of the disease 13.40±7.41; and HbA1c 8.25±0.95%). The research involved anthropometry of patients, general clinic examination. The following parameters were evaluated: levels of VD, C-terminal telopeptide (CTX), VDR genotyping analysis (VDR-FOKI, FokI (BseGI) and VDR-ApaI, ApaI).

Results: There was a substantial decrease in serum levels of VD in TID patients compared with the control (48.66±6.13 vs 123.47±15.49 nmol/l, P<0.001). There were significant differences in the levels of VD in patients with VDR, ApaI SNPs: wild homozygotes 37.5±8.12, in heterozygotes 44.2±12.35, in mutant homozygotes 71.29±16.36 nmol/l, P<0.001. Similar data were obtained among carriers individuals with VDR-FokI SNPs (27.32±4.89 vs 53.135±4.67 vs 58.2±7.7 nmol/l, P<0.001).

Conclusion: The results of the study reflect a significant decrease serum VD in patients with TID and VDR gene polymorphism’s influence on these processes to need further study.