Endocrine Abstracts

Primary hyperparathyroidism is a condition related with cardiovascular mortality and morbidity. Aim of this study is to investigate whether there is a difference between healthy controls, hypercalcemic patients with surgical decision and normocalcemic primary hyperparathyroidism patients for parameters like metabolic cardiovascular risk factors, carotis intima media thickness and pulse wave velocity and if there is a difference at patients with surgical decision 6 months after surgery or if there is a difference in patients with medical follow-up in time.

Seventeen hypercalcemic, 16 normocalcemic primary hyperparathyroidism patients, and 15 healthy controls were included to the study. Patient group was evaluated at the beginning and 6th month.

At the beginning of the study carotis intima media thickness was found higher at primary hyperparathyroidism patient group (patient group: 597±80 μm and control group: 529±91 μm, P=0.020). Likewise at the beginning pulse wave velocity was higher at hyperparathyroidism patient group than healthy control group (9.5±1.8 vs 7.7±0.8 m/s, P=0.000). Although there is a significant decrease at hypercalcemic patients for carotis intima media thickness after 6th month of the surgery (601±91 vs 541±65 μm, P=0.006), no difference occurred at normocalcemic patients at the end of the 6th month (P=0.686). Again there is a significant decrease at hypercalcemic patients for pulse wave velocity after 6th month of the surgery (9.6±1.8 vs 8.4±1.5 m/s, P=0.000), no difference occurred at normocalcemic patients at the end of the 6th month for pulse wave velocity (9.4±1.9 vs 10.0±1.9 m/s, P=0.196).

This result shows the importance of cardiovascular risk evaluation while making decision for treatment of primary hyperthyroidism patients and the need for earlier judgment makings for effective treatment options like surgery.