ECE2014 Poster Presentations Calcium and Vitamin D metabolism (68 abstracts)
Cardio-metabolic phenotyping of patients with familiar hypocalciuric hypercalcemia
Peter Wolf 1 , Martin Krssak 1, , Yvonne Winhofer 1 , Christian Anderwald 1, , Elisabeth Zwettler 3 , Siegfried Trattnig 2 , Anton Luger 1 , Sabina Baumgartner-Parzer 1 & Michael Krebs 1
1Division of Endocrinology and Metagolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; 2Department of Radiology, Centre of Excellence, High Field MR, Medical University of Vienna, AUVA Trauma Center, Vienna, Austria; 3Ludwig Boltzman Institute of Osteology, Hanusch Hospital of the WGKK, Vienna, Austria; 4Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy.
Introduction: Heterozygous inactivating mutations of the calcium sensing receptor (CaSR) gene cause mild alterations in calcium metabolism (familiar hypocalciuric hypercalcemia (FHH)). However, in addition to the parathyroid gland CaSR expression was recently identified in the myocardium and many other endocrine cells including pancreatic islet cells, entero-endocine cells and adipose tissue. So far, it is unknown whether FHH is associated with cardio-metabolic alterations that might be of clinical significance.
Methods: In eight FHH patients and nine controls matched for major anthropometric characteristics (45±6 years; BMI 29.5±2 kg/m2), ectopic lipid deposition and heart function were investigated using magnetic resonance spectroscopy and imaging. Oral glucose tolerance test derived indices for insulin-sensitivity and -secretion, and endocrine responses to systemic calcium stimulation were studied.
Results: Insulin sensitivity (CLIX 4.5±0.6 vs 4.3±0.4 mg/kg per min; OGIS 399±31 vs 419±17 ml/(min×m2), basal (insulin secretion rate 266±33 vs 218±25 pmol/min) and glucose stimulated β-cell function (IGI: 140±48 vs 118±21 pmol/mmol and adaptation index 180.2±12.2 vs 176.2±17.4) as well as calcium stimulated insulin secretion were comparable between FHH and controls respectively. Also ectopic lipid accumulation in the liver (13.7±15.4 vs 8.3±9.1%) and the myocardium (0.39±0.3 vs 0.32±0.1%) as well as systolic (ejection fraction 71.5±8 vs 72.8±8% and cardiac index 2.35±0.4 vs 2.35±0.5 ml/min per m2) and diastolic (E:A ratio 1.4±0.6 vs 1.3±0.7) myocardial function were not different between the groups.
Conclusion: Despite comprehensive cardio-metabolic phenotyping no clinically relevant alterations in myocardial function, lipid distribution, or glucose metabolism were observed. Thus, patients can be reassured that FHH reflects a laboratory finding with no need for intense medical surveillance.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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