ECE2014 Poster Presentations Calcium and Vitamin D metabolism (68 abstracts)
Correlations of vitamin D level with hormonal and biochemical parameters in polycystic ovary syndrome
Suna Kabil Kucur 1 , Ilay Gozukara 1 , Havva Yilmaz 3 , Aysenur Aksoy 4 , Eda Ulku Uludag 4 , Hulya Uzkeser 2 , Yasemin Kaya 5 , Esra Ademoglu 6 , Ayse Carlioglu 7 & Senay Arikan Durmaz 7
1Department of Gynecology and Obstetrics, University of Dumlupinar, Kutahya, Turkey; 2Department of Physical Medicine and Rehabilitation, Erzurum Regional Education and Research Hospital, Erzurum, Turkey; 3Department of Internal Medicine, Istanbul Medeniyet University, Istanbul, Turkey; 4Department of Gynecology and Obstetrics, Erzurum Nenehatun Dogumevi Hospital, Erzurum, Turkey; 5Ordu State Hospital, Ordu, Turkey; 6Department of Internal Medicine, Ankara Atatürk Education and Research Hospital, Erzurum, Turkey; 7Department of Endocrinology, Erzurum Regional Education and Research Hospital, Erzurum, Turkey.
Objective: To investigate the level of 25(OH) vitamin D (25(OH)D) and correlation between 25(OH)D level and hormonal-biochemical parameters in polycystic ovary syndrome (PCOS).
Materials and methods: Thirty-three patients diagnosed with PCOS and 42 age and BMI matched control group admitted to Erzurumm Regional Training and Research Hospital from May to October were included in the study. Serum total testosterone (TT), free testosterone (fT), 25(OH)D, DHEAS, LH, FSH, TSH, cortisol, 17αOH-progesterone, fasting glucose, and insulin levels were evaluated after 12 h fasting. HOMA-IR (fasting glucose level×fasting insulin/22.5) was calculated.
Results: Serum 17αOH progesterone and 25(OH)D levels were significantly lower in PCOS group (P<0.01). Serum LH, LH/ FSH TT, FT, insulin, ACTH, and DHEAS levels were significantly higher in PCOS group (P<0.01). There was statistically significant negative correlation of 25(OH)D levels with PCOS, LH/FSH, TT, fT, DHEAS, and FGS. There was no statistically significant correlation between 25(OH)D levels and age, BMI, and insulin resistance.
Conclusion: The results of this study indicated that vitamin D deficiency is highly prevalent among women with PCOS independent of BMI. We also demonstrated that vitamin D deficiency was correlated with hyperandrogenism in PCOS women. Low serum 25(OH)D levels might exacerbate PCOS symptoms. Large intervention trials are needed to evaluate the effect of vitamin D supplementation on hormonal and clinical parameters in PCOS women.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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