ECE2014 Poster Presentations Calcium and Vitamin D metabolism (68 abstracts)
Bone and vitamin D status in young male patients with relapsing kidney lithiasis and hypercalciuria
Dumitru Branisteanu 1 , Catalin Pricop 2 , Lacramioara Serban 3 , Dragomir Serban 3 , Alina Gatu 1 , Cristian Velicescu 5 , Didona Ungureanu 4 & Voichita Mogos 1
1Department of Endocrinology, University of Medicine and Pharmacy ‘Gr.T.Popa’, Iasi, Romania; 2Department of Urology, University of Medicine and Pharmacy ‘Gr.T.Popa’, Iasi, Romania; 3Department of Physiology, University of Medicine and Pharmacy ‘Gr.T.Popa’, Iasi, Romania; 4Department of Immunology and Genetics, Iasi, Romania; 5Department of Surgery, University of Medicine and Pharmacy ‘Gr.T.Popa’, Iasi, Romania.
Introduction: Idiopathic hypercalciuria is a risk factor for nephrolithiasis. Both renal stones and hypercalciuria are often associated with lower bone mineral density (BMD), but the relationship between these modifications is not completely understood. We aimed to evaluate some metabolic particularities possibly related to relapsing nephrolithiasis in young male patients.
Methods: We performed a cross-sectional study including a group of 30 young male patients with relapsing nephrolithiasis (group RN) and a group of 30 healthy, age and BMI matched controls (CTR). We evaluated calcium and phosphate in serum and 24 h urine samples, bone remodelling markers alkaline phosphatase (AP) and osteocalcin and lumbar and hip BMD.
Results: We observed higher values of serum calcium (P<0.05) and 24 h urinary calcium excretion (P<0.001) in the RN group. Although in the normal range, parathyroid hormone (PTH) and AP were also higher in the RN group (P<0.01). 25OH-D3 was lower than normal in many volunteers from both RN and CTR groups. However, 25OH-D3 was significantly lower in the RN group (20.2±11.9 vs 30.4±14.4 ng/ml, P<0.01). BMD, T- and Z-scores were lower in the RN group in both the lumbar (P<0.01) and hip (P<0.05) regions. 25OH-D3 levels were inversely correlated with PTH and directly correlated with lumbar and hip BMD in the RN group.
Conclusions: Young male patients with hypercalciuric RN seem to have lower BMD and higher bone turnover. Vitamin D deficiency may well be another environmental modification caused by modern life and favouring relapsing nehrolithiasis. Higher PTH levels related to vitamin D deficiency may contribute to bone demineralization in certain cases. Although still controversial, antiresorptive therapy, such as bisphosphonates, together with vitamin D repletion may be a logical therapeutic solution to prevent bone loss and also decrease calciuria and RN risk.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more