ECE2014 Poster Presentations Bone and Osteoporosis (36 abstracts)
Bone mineral density, bone turnover and vitamin D status in women with diabetes mellitus type 2 and healthy women with osteoporosis in menopause
Jovanka Novakovic-Paro , Ivana Bajkin , Dragana Tomic-Naglic , Milena Mitrovic , Tijana Icin , Bojan Vukovic , Radoslav Pejin , Djordje Popovic , Milica Medic-Stojanoska & Branka Kovacev-Zavisic
Clinic for Endocrinology, Diabetes and Metabolic Disorders, Medical Faculty, University of Novi Sad, Novi Sad, Vojvodina, Serbia.
Introduction: Literature data suggests increased fracture risk in women with diabetes mellitus type 2 but the underlying mechanism is not fully understood.
Aim of the study was to analyse bone turnover parameters in women with DM2 and in healthy women with osteoporosis in menopause.
Materials and methods: There were 76 participants out of wich 36 women with DM2. Average diabetes duration was 14.48±10.51 years with mean HbA1c 7.83±1.75%. Osteoporosis was diagnosed by hip and spine DXA scan. Osteocalcine, β-crosslaps and 25-OH-D were determined by ECLIA method on Elecsys machine.
Results: Women with DM2 compared to healthy women with osteoporosis: age (62.75±7.93 vs 63.92±7.21 god; P>0.05), body mass index (26.61±5.45 vs 25.84±4.34 kg/m2, P>0.05), spine bone mineral density (BMD) (0.839±0.084 vs 0.801±0.056 g/cm2, P<0.05), total hip BMD (0.752±0.109 vs 0.782±0.082 g/cm2, P>0.05), femur neck BMD (0.691±0.085 vs 0.742±0.084 g/cm2, P<0.05), osteocalcin (29.98±10.53 vs 33.11±8.56 ng/ml, P>0.05), β-crosslaps (530.59±225.58 vs 540.88±167.16 pg/ml, P>0.05), 25-OH-D (39.11±20.52 vs 38.85±17.38 nmol/l, P>0.05). Vitamin D deficiency (25OHD <30 nmol/l) was found in 41.7% women with DM2 and 37.5% healthy women, without statistical significance between groups.
Conclusion: Women with DM2 have significantly lower femur neck BMD. Statistical significance between bone turnover parameters, vitamin D status and vitamin D deficiency frequency between groups was not found. Further studies of complex mechanism of increased fracture risk in women with DM2 are needed.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more